Structural, mechanical and biomedical impacts of defects in Cu/Mg Co-doped ZnO nanoparticles

IF 3 Q2 PHYSICS, CONDENSED MATTER

Micro and Nanostructures Pub Date : 2025-09-22 DOI:10.1016/j.micrna.2025.208362

Kenan Senturk

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Abstract

Zn_0.99-xCu_0.01Mg_xO (x = 0–0.05) nanoparticles were synthesized by a sol–gel route and examined to relate doping-induced lattice defects to biocompatibility for prospective biomedical use. X-ray diffraction confirmed single-phase wurtzite with no secondary phases, while Williamson–Hall models provided crystallite size and lattice microstrain/stress, separating strain from size effects. Photoluminescence (UV–visible) showed an Mg-dependent defect redistribution suppression of the green band (V_O) with concomitant changes in Zn_i, V_Zn, and O_i centers. SEM/EDS verified the expected composition and quasi-spherical agglomerated morphology. Hemolysis assays on human erythrocytes revealed a monotonic decrease in lysis with increasing Mg; samples with x ≥ 0.04 were non-hemolytic at 1.0 mg/mL (ISO <5 %). Overall, Mg-enabled defect passivation particularly V_O suppression correlates with improved blood compatibility, indicating that Cu/Mg co-doping is a practical lever to tailor ZnO nanoparticles for blood-contacting coatings, sensors, and implant interfaces.

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Cu/Mg共掺杂ZnO纳米粒子缺陷的结构、力学和生物医学影响

采用溶胶-凝胶法合成了Zn0.99-xCu0.01MgxO （x = 0-0.05）纳米粒子，并研究了掺杂诱导的晶格缺陷与生物相容性之间的关系。x射线衍射证实了单相纤锌矿没有二次相，而Williamson-Hall模型提供了晶体尺寸和晶格微应变/应力，将应变与尺寸效应分离开来。光致发光（紫外可见）显示出镁依赖的绿带（VO）缺陷再分布抑制，并伴随Zni， VZn和Oi中心的变化。SEM/EDS验证了预期的成分和准球形团聚形貌。人红细胞溶血实验显示，随着Mg的增加，溶血量单调下降；x≥0.04的样品在1.0 mg/mL （ISO < 5%）时无溶血作用。总的来说，Mg使缺陷钝化，特别是VO抑制与血液相容性的改善相关，表明Cu/Mg共掺杂是定制ZnO纳米颗粒用于血液接触涂层，传感器和植入物界面的实用手段。

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来源期刊

Micro and Nanostructures

CiteScore

6.50

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0.00%

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