Feline Circovirus-1 in domestic cats: A multicentric European epidemiological study

IF 1.8 3区农林科学 Q1 VETERINARY SCIENCES

Research in veterinary science Pub Date : 2025-10-01 DOI:10.1016/j.rvsc.2025.105920

Violetta Iris Vasinioti , Anna Salvaggiulo , Francesco Pellegrini , Georgia Diakoudi , Michele Camero , João Rodrigo Mesquita , Sónia Gomes-de-Sá , Ioana Buzdugan , Gheorghe Savuţa , Gabriella Elia , Nicola Decaro , Vito Martella , Gianvito Lanave

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引用次数: 0

Abstract

Members of the family Circoviridae (circovirids) have been identified in several animal species and in human specimens. Circoviruses (CVs) are pathogenic for swine and birds whilst they have been associated with gastro-intestinal, respiratory disorders and systemic disease in dogs. Recently, a novel feline CV (FeCV-1) has been identified as a predominant circovirus population in fecal samples of cats in a study in Italy. To better assess the circulation of FeCV-1 in the feline population, in the present study, we investigated the prevalence of FeCV-1 in samples (rectal and oropharyngeal swabs, and blood) of domestic cats collected from Greece, Romania, and Portugal. A quantitative PCR assay specific for FeCV-1 was used for molecular screening. Overall, 22 (11.8 %) out of 187 samples tested positive for FeCV-1 with a prevalence of 20.4 % (10/49) in Greek samples, 15.9 % (7/44) in Romanian samples, and 5.4 % (5/94) in Portuguese samples. FeCV-1 was detected in both fecal and respiratory samples. The whole genome sequence was determined for eight variants. The FeCV-1 genomes determined in this study shared 95.2 % to 99.6 % nt identity to the initial variants (OQ357577 -OQ357579) detected in Italy, forming a well-conserved clade. These findings suggest that FeCV-1 is a common component of the feline virome. Understanding the pathogenic role, if any, of FeCV-1 in cats will be necessary in prospective studies.

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家猫中的猫圆环病毒-1：一项多中心欧洲流行病学研究

已在若干动物物种和人类标本中发现圆环病毒科（圆环病毒）成员。圆环病毒（CVs）对猪和鸟类具有致病性，同时它们与狗的胃肠道、呼吸系统疾病和全身性疾病有关。最近，在意大利的一项研究中，一种新的猫CV （FeCV-1）已被确定为猫粪便样本中的主要环状病毒种群。为了更好地评估FeCV-1在猫科动物群体中的循环，在本研究中，我们调查了从希腊、罗马尼亚和葡萄牙收集的家猫样本（直肠、口咽拭子和血液）中FeCV-1的流行情况。采用FeCV-1特异性定量PCR方法进行分子筛选。总体而言，187个样本中有22个（11.8%）FeCV-1检测呈阳性，其中希腊样本患病率为20.4%(10/49)，罗马尼亚样本患病率为15.9%(7/44)，葡萄牙样本患病率为5.4%（5/94）。在粪便和呼吸道样本中均检测到FeCV-1。确定了8个变异的全基因组序列。本研究确定的FeCV-1基因组与在意大利检测到的初始变异（OQ357577 -OQ357579）具有95.2%至99.6%的同源性，形成了一个保守性良好的进化支。这些发现表明，FeCV-1是猫病毒群的共同组成部分。了解FeCV-1在猫中的致病作用（如果有的话）在前瞻性研究中是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in veterinary science 农林科学-兽医学

CiteScore

4.40

自引率

4.20%

发文量

312

审稿时长

75 days

期刊介绍： Research in Veterinary Science is an International multi-disciplinary journal publishing original articles, reviews and short communications of a high scientific and ethical standard in all aspects of veterinary and biomedical research. The primary aim of the journal is to inform veterinary and biomedical scientists of significant advances in veterinary and related research through prompt publication and dissemination. Secondly, the journal aims to provide a general multi-disciplinary forum for discussion and debate of news and issues concerning veterinary science. Thirdly, to promote the dissemination of knowledge to a broader range of professions, globally. High quality papers on all species of animals are considered, particularly those considered to be of high scientific importance and originality, and with interdisciplinary interest. The journal encourages papers providing results that have clear implications for understanding disease pathogenesis and for the development of control measures or treatments, as well as those dealing with a comparative biomedical approach, which represents a substantial improvement to animal and human health. Studies without a robust scientific hypothesis or that are preliminary, or of weak originality, as well as negative results, are not appropriate for the journal. Furthermore, observational approaches, case studies or field reports lacking an advancement in general knowledge do not fall within the scope of the journal.