Enhancing 5-fluorouracil delivery: Core-shell vs. blended polycaprolactone/thermoplastic polyurethane electrospun comparative evaluation

IF 3.4 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society Pub Date : 2025-09-30 DOI:10.1016/j.jics.2025.102150

Degu Melaku Kumelachew , Fujun Wang , Chaojing Li , Lu Wang

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Abstract

Localized 5-fluorouracil (5-FU) delivery via stent-integrated electrospun fibers offers promise for mitigating systemic toxicity in gastrointestinal cancer therapy. This study compares core-shell (polycaprolactone/5-fluorouracil core; thermoplastic polyurethane/calcium carbonate shell) (PCL/5-FU core; TPU/CaCO₃ shell) and blended (thermoplastic polyurethane/polycaprolactone/5-fluorouracil/calcium carbonate) (TPU/PCL/5-FU/CaCO₃) electrospun fibers for mechanical stability and controlled drug release in stent applications. Fibers were fabricated via coaxial electrospinning (core: 0.8 mL per hour (mL/h), shell: 0.3 mL per hour (mL/h), 19 kV (kV)). Morphology (scanning electron microscopy/transmission electron microscopy) (SEM/TEM), composition (Fourier-transform infrared spectroscopy/X-ray photoelectron spectroscopy/X-ray diffraction) (FTIR/XPS/XRD), thermal properties (differential scanning calorimetry/thermogravimetric analysis) (DSC/TGA), hydrophilicity (contact angle), and mechanical performance (tensile testing) were characterized. In vitro 5-fluorouracil (5-FU) release kinetics (phosphate buffered saline, pH 7.4) (PBS) were modeled using Korsmeyer-Peppas. Core-shell fibers exhibited distinct core-sheath architecture (transmission electron microscopy) (TEM), enhanced tensile strength (7.5 MPa (MPa) vs. blended: 7 MPa (MPa)), higher hydrophobicity (82.55° (°) vs. 75.5° (°)), and superior drug retention. X-ray diffraction/Fourier-transform infrared spectroscopy (XRD/FTIR) confirmed 5-fluorouracil (5-FU) encapsulation and component integration. Drug release followed anomalous transport (blended: K = 0.1994, n = 0.76) versus super case-II kinetics (core-shell: K = 0.00384, n = 1.51), indicating prolonged, diffusion-erosion–modulated release. Core-shell fibers demonstrate optimal mechanical resilience (>50 % higher modulus) and sustained 5-fluorouracil (5-FU) delivery, supporting their utility in drug-eluting stents for gastrointestinal malignancies.

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增强5-氟尿嘧啶输送：核壳与混合聚己内酯/热塑性聚氨酯静电纺丝的比较评价

5-氟尿嘧啶（5-FU）通过支架植入的电纺丝纤维局部输送，为减轻胃肠道癌症治疗的全身毒性提供了希望。本研究比较了核-壳（聚己内酯/5-氟尿嘧啶芯；热塑性聚氨酯/碳酸钙壳）（PCL/5-FU芯；TPU/CaCO3壳）和共混（热塑性聚氨酯/聚己内酯/5-氟尿嘧啶/碳酸钙）（TPU/PCL/5-FU/CaCO3）电纺丝纤维在支架应用中的机械稳定性和药物释放控制。同轴静电纺丝制备纤维(芯：0.8 mL/h (mL/h)，壳：0.3 mL/h （mL/h), 19 kV (kV)）。形貌（扫描电镜/透射电镜）（SEM/TEM）、成分（傅里叶变换红外光谱/ x射线光电子能谱/ x射线衍射）（FTIR/XPS/XRD）、热性能（差示扫描量热法/热重分析）（DSC/TGA）、亲水性（接触角）和力学性能（拉伸测试）进行了表征。采用Korsmeyer-Peppas法模拟5-氟尿嘧啶（5-FU）体外（pH 7.4的磷酸盐缓冲盐水）释放动力学。核-壳纤维表现出独特的核-鞘结构（透射电子显微镜）（TEM），增强的抗拉强度(7.5 MPa (MPa) vs.共混：7 MPa (MPa))，更高的疏水性（82.55°（°）vs. 75.5°（°）），以及优越的药物潴留。x射线衍射/傅里叶变换红外光谱（XRD/FTIR）证实了5-氟尿嘧啶（5-FU）的包封和组分集成。药物释放遵循异常转运（混合：K = 0.1994, n = 0.76）和超级病例- ii动力学（核-壳：K = 0.00384, n = 1.51），表明延长的扩散侵蚀调节释放。核壳纤维表现出最佳的机械弹性（模量提高50%）和持续的5-氟尿嘧啶（5-FU）递送，支持其在胃肠道恶性肿瘤药物洗脱支架中的应用。

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来源期刊

Journal of the Indian Chemical Society 化学-化学综合

CiteScore

3.50

自引率

7.70%

发文量

492

审稿时长

3-8 weeks

期刊介绍： The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.