Advancing the understanding of alveolar regeneration: Global research trends, thematic evolution, and emerging frontiers

IF 3.5 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING

Regenerative Therapy Pub Date : 2025-09-30 DOI:10.1016/j.reth.2025.09.005

Si-Cheng Zhou , Ying-Xian Dong , Jie Tian , Guo-Wei Che , Yutian Lai

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引用次数: 0

Abstract

Background

Alveolar regeneration represents a critical research direction in respiratory disease treatment. Despite the surge in studies following the COVID-19 pandemic, comprehensive bibliometric analysis to systematically evaluate global research trends and future directions remains lacking.

Methods

This study employed bibliometric methodology to analyze 1564 publications related to alveolar regeneration from 1974 to 2024 using the Web of Science Core Collection database. Data visualization and analysis were conducted using VOSviewer (version 1.6.19), CiteSpace (version 6.2.R3), and the biblioshiny R package.

Results

The analysis encompassed 68 countries, 1930 institutions, and 9150 researchers across 658 journals. The United States leads with 601 publications and 32,172 citations, with Harvard University as the most influential institution. The American Journal of Respiratory and Critical Care Medicine has the highest impact factor (19.3), while the American Journal of Physiology-Lung Cellular and Molecular Physiology has the most co-citations (2,402). Edward E. Morrisey is the most prolific author, and C. E. Barkauskas has the highest co-citations. Keyword analysis revealed six major research clusters: stem cells and regenerative medicine, acute lung injury and fibrosis, COVID-19-related research, chronic lung disease repair, cellular behavior and molecular mechanisms, and post-pneumonectomy regeneration. Thematic mapping indicates future research should prioritize lung injury repair mechanisms, matrix environment in tissue regeneration, stem cell therapeutics, and immune regulation in lung injury repair.

Conclusion

This first comprehensive 50-year bibliometric analysis of alveolar regeneration reveals the evolutionary trend from basic mechanistic exploration toward clinical translational applications, providing important reference for researchers and funding agencies.

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推进对牙槽骨再生的理解：全球研究趋势、专题演变和新兴前沿

背景肺泡再生是呼吸系统疾病治疗的一个重要研究方向。尽管COVID-19大流行后研究激增，但仍缺乏全面的文献计量分析来系统评估全球研究趋势和未来方向。方法采用文献计量学方法，对Web of Science Core Collection数据库中1974 ~ 2024年间1564篇与肺泡再生相关的文献进行分析。使用VOSviewer（1.6.19版本）、CiteSpace（6.2版本）对数据进行可视化分析。R3)和biblioshiny R包。该分析涵盖了68个国家、1930个机构和658种期刊的9150名研究人员。美国以601篇论文和32172次引用领先，哈佛大学是最具影响力的机构。《美国呼吸与重症监护医学杂志》的影响因子最高（19.3），而《美国生理学杂志-肺细胞和分子生理学》的共被引次数最多（2,402）。爱德华·莫里西（Edward E. Morrisey）是最多产的作家，C. E. Barkauskas的共被引次数最多。关键词分析揭示了六大研究集群：干细胞与再生医学、急性肺损伤与纤维化、covid -19相关研究、慢性肺部疾病修复、细胞行为与分子机制、肺切除术后再生。主题映射表明，未来的研究应优先考虑肺损伤修复机制、组织再生中的基质环境、干细胞治疗和肺损伤修复中的免疫调节。结论本研究首次对肺泡再生进行了近50年的文献计量学分析，揭示了肺泡再生从基础机制探索到临床转化应用的进化趋势，为研究人员和资助机构提供了重要参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.