Unveiling Sec31: The regulator of COPII vesicle-dependent secretion and beyond

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-09-22 DOI:10.1016/j.isci.2025.113612

Jiaming Nie , Jingzhi Ma

引用次数: 0

Abstract

Sec31, the outer protein of the coat protein complex II (COPII) vesicle, is recognized as a key regulator of the dynamics of COPII assembly and disassembly, thereby regulating the transport of newly synthesized cargo from the endoplasmic reticulum (ER) to the Golgi complex. In the context of large cargo, such as collagen, Sec31 is capable of modulating the flexibility of the outer shell to ensure precise transportation. In addition to its role in secretion, Sec31 is implicated in various physiological and pathological processes, including autophagy and responses to microbial infections. This review summarizes the functions of Sec31 and its molecular mechanisms.

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揭秘Sec31: COPII囊泡依赖性分泌及其他的调节因子

外壳蛋白复合物II （COPII）囊泡的外层蛋白Sec31被认为是COPII组装和拆卸动力学的关键调节剂，从而调节新合成的货物从内质网（ER）到高尔基复合体的运输。对于大型货物，如胶原蛋白，Sec31能够调节外壳的灵活性，以确保精确运输。除了在分泌中发挥作用外，Sec31还参与多种生理和病理过程，包括自噬和对微生物感染的反应。本文就Sec31的功能及其分子机制作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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