Punishment of ethanol choice in group-housed male cynomolgus monkeys

IF 3.6 2区 医学 Q1 PSYCHIATRY
EA Cronin, PM Epperly, AP Floge, PW Czoty
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Abstract

Background

A common characteristic of individuals with alcohol use disorder (AUD) is that they continue to consume alcohol despite adverse consequences. A better understanding of the factors that influence this relative insensitivity to punishment may help identify novel treatments for AUD. In animal models, this characteristic can be studied by adding the bitter-tasting alkaloid, quinine, to an ethanol solution. In the present study, punishment of ethanol drinking was assessed in socially housed male cynomolgus monkeys to determine whether sensitivity to punishment is influenced by a monkey’s position in the social hierarchy. Methods: Ten adult male cynomolgus monkeys with 4.5 years of experience drinking ethanol were given concurrent access to a 4 % ethanol solution and a 0.5 % Tang solution for 3 h each day, 5 days per week. When ethanol choice was stable, a single quinine concentration (0.003–5.6 g/L) was added to the ethanol solution for one day. This was repeated until a full quinine concentration-effect curve was created. Results: Addition of quinine produced a concentration-dependent decrease in ethanol choice and intake. The potency of quinine to decrease ethanol choice did not differ significantly between socially dominant and socially subordinate monkeys. However, only in dominant monkeys were significant positive relationships found between quinine EC50 values and both the volume of ethanol consumed at baseline and baseline ethanol intake.

Conclusions

These results demonstrate the ability of quinine to produce robust punishment of ethanol choice and suggest that the chronic subordination stress experienced by the low-ranking monkeys alters sensitivity to punishment.
群居雄性食蟹猴对乙醇选择的惩罚
酒精使用障碍(AUD)患者的一个共同特征是,尽管有不良后果,他们仍继续饮酒。更好地了解影响这种对惩罚相对不敏感的因素可能有助于确定AUD的新治疗方法。在动物模型中,可以通过向乙醇溶液中加入苦味生物碱奎宁来研究这一特性。在本研究中,我们评估了社会饲养的雄性食蟹猴对酒精饮酒的惩罚,以确定对惩罚的敏感性是否受到猴子在社会等级中的地位的影响。方法:10只具有4.5年乙醇饮用经验的成年雄性食蟹猴,每周5天,每天3小时,同时使用4%乙醇溶液和0.5%唐溶液。当乙醇选择稳定时,加入单一浓度的奎宁(0.003-5.6 g/L),乙醇溶液1天。重复这一过程,直到形成完整的奎宁浓度-效应曲线。结果:奎宁的加入使乙醇的选择和摄入量呈浓度依赖性降低。奎宁减少乙醇选择的效力在社会优势和社会从属猴子之间没有显著差异。然而,只有在优势猴中,奎宁EC50值与基线和基线乙醇摄入量之间存在显著的正相关关系。结论奎宁对低等级猕猴的乙醇选择产生了较强的惩罚效应,表明低等级猕猴的长期服从应激改变了其对惩罚的敏感性。
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来源期刊
Drug and alcohol dependence
Drug and alcohol dependence 医学-精神病学
CiteScore
7.40
自引率
7.10%
发文量
409
审稿时长
41 days
期刊介绍: Drug and Alcohol Dependence is an international journal devoted to publishing original research, scholarly reviews, commentaries, and policy analyses in the area of drug, alcohol and tobacco use and dependence. Articles range from studies of the chemistry of substances of abuse, their actions at molecular and cellular sites, in vitro and in vivo investigations of their biochemical, pharmacological and behavioural actions, laboratory-based and clinical research in humans, substance abuse treatment and prevention research, and studies employing methods from epidemiology, sociology, and economics.
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