The antioxidant effect of resveratrol on leukocytes from patients with Alzheimer is independent of SIRT1 signaling pathway

IF 2.2 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2025-10-01 DOI:10.1016/j.bbrep.2025.102291

Filipe Nogueira Franco, Luciana de Cassia Cardoso, Bárbara Néllita Moura Silva, Glaucy Rodrigues de Araújo, Miriam Martins Chaves

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Abstract

Alzheimer's Disease (AD) is the most prevalent dementia in aging. Among its aspects is cognitive and functional decline, resulting from an increase in Reactive Oxygen Species (ROS) and Nitrogen (RNS). Resveratrol (RSV) is a polyphenolic compound that has been recognized as a potent antioxidant. The objective was to verify the oxidative profile of AD in leukocytes, correlating the main oxidative parameters with the functionality of these elderly individuals and verify the antioxidant effect of RSV. For this, ROS and RNS, the antioxidant enzymes catalase and glutathione peroxidase (GPx), as well as the action of the SIRT1 on leukocytes of elderly people without and with AD, in the presence and absence of RSV, were evaluated. It was observed that RSV, despite acting in the AD group, had its antioxidant power reduced compared to the group without AD. RSV was able to increase GPx in both groups. Analyzing SIRT1, we observe the silencing of this signaling pathway in leukocytes from AD. AD was more dependent on the Katz index. Therefore, we observed that oxidative stress predisposes to an increased loss of autonomy and independence in AD and that the antioxidant effect of RSV is reduced.

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白藜芦醇对阿尔茨海默病患者白细胞的抗氧化作用与SIRT1信号通路无关

阿尔茨海默病（AD）是最常见的老年痴呆症。其中一个方面是由于活性氧（ROS）和氮（RNS）的增加而导致的认知和功能下降。白藜芦醇（RSV）是一种多酚化合物，被认为是一种有效的抗氧化剂。目的是验证AD在白细胞中的氧化谱，将主要氧化参数与这些老年人的功能联系起来，并验证RSV的抗氧化作用。在RSV存在和不存在的情况下，对无AD和AD老年人的ROS和RNS、过氧化氢酶和谷胱甘肽过氧化物酶（GPx）抗氧化酶以及SIRT1对白细胞的作用进行了评价。我们观察到，尽管RSV在AD组中起作用，但与未AD组相比，其抗氧化能力降低。RSV均能使两组的GPx升高。通过分析SIRT1，我们观察到AD白细胞中该信号通路的沉默。AD更依赖于Katz指数。因此，我们观察到氧化应激易导致AD患者自主性和独立性丧失增加，并且RSV的抗氧化作用降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.