Syntheses of Pyrene-4,5-dione and Pyrene-4,5,9,10-tetraone

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-10-04 DOI:10.1021/acs.joc.5c01542

Omolola Balogun, Besan Khader, Tetyana Ignatova, Aleksandrs Prokofjevs

引用次数: 0

Abstract

Improved gram scale synthesis procedures for the preparation of pyrene-4,5-dione and pyrene-4,5,9,10-tetraone are reported. Pyrene-4,5-dione has been synthesized using potassium persulfate as the oxidant and RuO₂·nH₂O as the catalyst in the biphasic CH₂Cl₂/H₂O solvent mixture containing K₂CO₃ as the base. We also developed several procedures for multigram scale oxidation of pyrene-4,5-dione to pyrene-4,5,9,10-tetraone, eliminating the need for chromatographic purification of the poorly soluble tetraone product.

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吡咯-4,5-二酮和吡咯-4,5,9,10-四酮的合成

报道了改进的克级合成方法，制备了吡咯-4,5-二酮和吡咯-4,5,9,10-四酮。在以K2CO3为碱的CH2Cl2/H2O双相溶剂混合物中，以过硫酸钾为氧化剂，以RuO2·nH2O为催化剂合成了吡咯-4,5-二酮。我们还开发了几种将芘-4,5-二酮多图氧化为芘-4,5,9,10-四酮的方法，从而消除了对难溶性四酮产品进行色谱纯化的需要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.