Stage-dependent cerebrocerebellar communication during sensorimotor processing.

IF 15.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications Pub Date : 2025-10-03 DOI:10.1038/s41467-025-64592-8

Vincenzo Romano,Matthijs van Driessche,Nathalie van Wingerden,Staf Bauer,Brendan Boeser,Jorge F Mejias,Chris I De Zeeuw

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Abstract

Cerebral cortex and cerebellum are essential for sensorimotor control, but the dynamics of their interactions remain unclear. Here, we investigated which pathways prevail during preparation and execution of spontaneous whisker movements in mice. During preparation, neuronal activity of primary motor (M1) and somatosensory (S1) cortex precede that of cerebellar crus regions, with a lead that is consistent with relaying a copy of motor commands. After movement onset, the phase of the signal inverts, indicating a dominant vector signaling from cerebellum to cerebrum. At this stage, Purkinje cell activity correlates more with S1 than M1, generating a prediction of sensory consequences during motor actions. A computational cerebello-cortical model could replicate the changes in dynamics and directionality. Optogenetic manipulations of pons and thalamus confirm the modeled predictions on stage-dependent dynamics. Together our data point towards a swap in direction of information flow between cerebrum and cerebellum when motor preparation switches to execution.

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感觉运动加工过程中阶段依赖的脑小脑通讯。

大脑皮层和小脑对感觉运动控制至关重要，但它们相互作用的动力学尚不清楚。在这里，我们研究了在小鼠自发须运动的准备和执行过程中哪些途径占上风。在准备过程中，初级运动皮层（M1）和体感皮层（S1）的神经元活动先于小脑小腿区域，这与传递运动命令的拷贝一致。运动开始后，信号的相位反转，表明从小脑到大脑的显性矢量信号。在这个阶段，浦肯野细胞的活性与S1的相关性大于与M1的相关性，从而对运动过程中的感觉结果产生预测。计算小脑-皮质模型可以复制动态和方向性的变化。脑桥和丘脑的光遗传学操作证实了对阶段依赖动力学的建模预测。总的来说，我们的数据表明，当运动准备切换到执行时，大脑和小脑之间的信息流方向发生了交换。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.