{"title":"Fluid Mechanics of Blood Cells and Vesicles Squeezing Through Narrow Constrictions","authors":"Zhangli Peng, Annie Viallat, Yuan-Nan Young","doi":"10.1146/annurev-fluid-112723-052727","DOIUrl":null,"url":null,"abstract":"The squeezing of blood cells and vesicles through narrow constrictions, such as splenic slits, pulmonary capillaries, vascular endothelial gaps, and microfluidic channels, is crucial in physiology and biotechnology, with fluid mechanics playing a central role. The diverse geometries of these constrictions, the associated flow conditions, and the unique mechanical properties of cells and vesicles create a rich subject in fluid mechanics emerging from nonlinear dynamics of fluid–structure interactions involving both lubrication and Marangoni flows. Advances in microfluidics, video microscopy, and computational modeling have enabled investigations into these complex processes. This review surveys the key features and approaches, recent prominent studies, and unresolved challenges related to these processes, offering insights for researchers across biomechanics, biomedical engineering, biological physics, hematology, physiology, and applied mathematics.","PeriodicalId":50754,"journal":{"name":"Annual Review of Fluid Mechanics","volume":"99 1","pages":""},"PeriodicalIF":30.2000,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual Review of Fluid Mechanics","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1146/annurev-fluid-112723-052727","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MECHANICS","Score":null,"Total":0}
引用次数: 0
Abstract
The squeezing of blood cells and vesicles through narrow constrictions, such as splenic slits, pulmonary capillaries, vascular endothelial gaps, and microfluidic channels, is crucial in physiology and biotechnology, with fluid mechanics playing a central role. The diverse geometries of these constrictions, the associated flow conditions, and the unique mechanical properties of cells and vesicles create a rich subject in fluid mechanics emerging from nonlinear dynamics of fluid–structure interactions involving both lubrication and Marangoni flows. Advances in microfluidics, video microscopy, and computational modeling have enabled investigations into these complex processes. This review surveys the key features and approaches, recent prominent studies, and unresolved challenges related to these processes, offering insights for researchers across biomechanics, biomedical engineering, biological physics, hematology, physiology, and applied mathematics.
期刊介绍:
The Annual Review of Fluid Mechanics is a longstanding publication dating back to 1969 that explores noteworthy advancements in the field of fluid mechanics. Its comprehensive coverage includes various topics such as the historical and foundational aspects of fluid mechanics, non-newtonian fluids and rheology, both incompressible and compressible fluids, plasma flow, flow stability, multi-phase flows, heat and species transport, fluid flow control, combustion, turbulence, shock waves, and explosions.
Recently, an important development has occurred for this journal. It has transitioned from a gated access model to an open access platform through Annual Reviews' innovative Subscribe to Open program. Consequently, all articles published in the current volume are now freely accessible to the public under a Creative Commons Attribution (CC BY) license.
This new approach not only ensures broader dissemination of research in fluid mechanics but also fosters a more inclusive and collaborative scientific community.