Signalling molecules and microenvironment modulation in skin regeneration of chronic wound repair: A cellular perspective.

IF 2 4区 生物学 Q3 DEVELOPMENTAL BIOLOGY
Keren Celestina Mendonce, Naveen Palani, P Monisha, Parthasarathy Surya, Suriyaprakash Rajadesingu
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Abstract

Tissue repair is an intricate biological process involving cellular and molecular mechanisms. These mechanisms coordinate the repair of damaged tissue, relying on the function of several signalling molecules. Growth factors, cytokines, and hormones perform a fundamental role in tissue regeneration, especially in skin regeneration. On the other hand, in case of diabetes or chronic wounds, the synthesis and regulation of these signalling molecules may be disrupted. Despite advances in medical science, chronic, non-healing wounds remain a continuous challenge, often characterized by reduced angiogenesis, impaired epithelialization, irregular granulation tissue formation, and elevated inflammation. This highlights the need to explore their therapeutic applications and the possibility of external production or stimulation for improved healing. The cellular intricacies are revealed within the wounded environment, explaining the functions of each signalling molecule, thus providing a roadmap for therapeutic exploration. It scrutinizes the complexities of venous and arterial ulcers, diabetic wounds, and complex burn wounds, which indicates the urgency of coming up with innovative interventions. From the modulation of wound microenvironments will arise new treatment modalities that spur tissue restoration with efficacy. Scientists have explored the wound healing properties of Vascular Endothelial Growth Factor, Platelet Derived Growth Factor, Transforming Growth Factor-β, granulocyte-macrophage colony-stimulating factor, estradiol benzoate, thyroxine, and erythropoietin. This review article acts as a guide for better treatments that can improve wound healing.

信号分子和微环境调节在皮肤再生的慢性伤口修复:一个细胞的观点。
组织修复是一个复杂的生物学过程,涉及细胞和分子机制。这些机制依赖于几个信号分子的功能来协调受损组织的修复。生长因子、细胞因子和激素在组织再生,尤其是皮肤再生中起着重要作用。另一方面,在糖尿病或慢性创伤的情况下,这些信号分子的合成和调节可能会被破坏。尽管医学科学取得了进步,但慢性、不愈合的伤口仍然是一个持续的挑战,通常以血管生成减少、上皮化受损、不规则肉芽组织形成和炎症升高为特征。这突出了探索其治疗应用和外部生产或刺激改善愈合的可能性的必要性。在受伤的环境中揭示了细胞的复杂性,解释了每个信号分子的功能,从而为治疗探索提供了路线图。它仔细研究了静脉和动脉溃疡、糖尿病伤口和复杂烧伤伤口的复杂性,这表明提出创新干预措施的紧迫性。从伤口微环境的调节将产生新的治疗方式,刺激组织恢复与有效。科学家们探索了血管内皮生长因子、血小板衍生生长因子、转化生长因子-β、粒细胞-巨噬细胞集落刺激因子、苯甲酸雌二醇、甲状腺素和促红细胞生成素的伤口愈合特性。这篇综述文章作为指导更好的治疗可以提高伤口愈合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cells & Development
Cells & Development DEVELOPMENTAL BIOLOGY-
CiteScore
3.70
自引率
0.00%
发文量
33
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