Three-dimensional quantitative elastography using micro-ultrasound: Proof of concept

IF 4.1 2区物理与天体物理 Q1 ACOUSTICS

Ultrasonics Pub Date : 2025-09-26 DOI:10.1016/j.ultras.2025.107811

Reid Vassallo , Tajwar Abrar Aleef , Qi Zeng , Vedanth Desaigoudar , Brian Wodlinger , Miles P. Mannas , Peter C. Black , Septimiu E. Salcudean

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引用次数: 0

Abstract

Prostate cancer (PCa) is one of the most frequently diagnosed cancers worldwide, yet there are still limitations to overcome in its diagnostic workflow. Some of these limitations may be addressed by quantitative elastography and micro-ultrasound (microUS). This paper presents the first implementation of volumetric shear wave absolute vibro-elastography (S-WAVE) using the ExactVu™ microUS system. This implementation uses minimal additional hardware, making it conducive to insertion into the clinical workflow. In order to accurately recreate phasors with a frame rate below the Nyquist sampling rate for the excitation frequencies, a bandpass sampling strategy is employed for tissue motion tracing. This method is validated using a commercial quality assurance phantom, with inclusions of varying stiffness levels within a homogeneous background. All four inclusions could be visualized with the expected relative stiffness values, and the background stiffness could be measured repeatedly. This demonstrates the effectiveness of microUS-based S-WAVE imaging for the future detection of PCa lesions.

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使用微超声的三维定量弹性成像：概念证明。

前列腺癌（PCa）是世界范围内最常见的癌症之一，但在其诊断流程中仍有一些局限性需要克服。其中一些限制可以通过定量弹性成像和微超声（microUS）来解决。本文介绍了使用ExactVu™microrous系统首次实现的体积剪切波绝对振动弹性成像（S-WAVE）。这种实现使用最少的额外硬件，使其有利于插入临床工作流程。为了准确再现激励频率下帧率低于奈奎斯特采样率的相量，采用带通采样策略进行组织运动跟踪。该方法使用商业质量保证模型进行验证，在均匀背景中具有不同刚度水平的夹杂物。四种包裹体均可显示出期望的相对刚度值，背景刚度可重复测量。这证明了基于微rouss - wave成像在未来检测前列腺癌病变方面的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasonics 医学-核医学

CiteScore

7.60

自引率

19.00%

发文量

186

审稿时长

3.9 months

期刊介绍： Ultrasonics is the only internationally established journal which covers the entire field of ultrasound research and technology and all its many applications. Ultrasonics contains a variety of sections to keep readers fully informed and up-to-date on the whole spectrum of research and development throughout the world. Ultrasonics publishes papers of exceptional quality and of relevance to both academia and industry. Manuscripts in which ultrasonics is a central issue and not simply an incidental tool or minor issue, are welcomed. As well as top quality original research papers and review articles by world renowned experts, Ultrasonics also regularly features short communications, a calendar of forthcoming events and special issues dedicated to topical subjects.