Role of post-translational modifications in virulence of Bacillus anthracis: A narrative review.

IF 3.4 4区生物学 Q3 MICROBIOLOGY

Research in microbiology Pub Date : 2025-09-30 DOI:10.1016/j.resmic.2025.104344

Renu Baweja, Hema Rajput, Prateek Bhardwaj, Aakriti Gangwal, B S Balaji, Yogendra Singh

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引用次数: 0

Abstract

Bacillus anthracis, a rod-shaped, spore-forming bacterium, is the causative agent of anthrax. The life cycle of B. anthracis involves sporulation and germination processes that are precisely regulated by distinct sigma factors and associated proteins. Its pathogenicity is primarily attributed to a tripartite toxin consisting of lethal factor (LF), edema factor (EF) and protective antigen (PA), as well as an antiphagocytic capsule of Poly-γ-D-Glutamate. The virulence of B. anthracis is further regulated by various post-translational modifications (PTMs), including protein phosphorylation, acetylation, glycosylation, hydroxylation, and lipidation. These modifications play a key role in modulating bacterial virulence by influencing enzymatic activity and protein expression. This review summarizes the role of PTMs in the regulation of B. anthracis virulence. A deeper understanding of how these PTMs contribute to B. anthracis pathogenesis may offer new insights into novel enzyme targets, strategies to disrupt toxin production and the development of therapeutic approaches to combat anthrax infections.

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翻译后修饰在炭疽芽孢杆菌毒力中的作用：综述。

炭疽芽孢杆菌是一种杆状的芽孢形成细菌，是炭疽的病原体。炭疽芽孢杆菌的生命周期包括产孢和萌发过程，这些过程受到不同的sigma因子和相关蛋白的精确调节。其致病性主要归因于一种由致死性因子（LF）、水肿因子（EF）和保护性抗原（PA）组成的三方毒素，以及聚γ- d -谷氨酸抗吞噬胶囊。炭疽芽胞杆菌的毒力进一步受到多种翻译后修饰（PTMs）的调控，包括蛋白磷酸化、乙酰化、糖基化、羟基化和脂化。这些修饰通过影响酶活性和蛋白质表达在调节细菌毒力中起关键作用。本文就ptm在炭疽芽孢杆菌毒力调控中的作用作一综述。更深入地了解这些ptm如何促进炭疽杆菌的发病机制，可能为新的酶靶点、破坏毒素产生的策略和对抗炭疽感染的治疗方法的发展提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in microbiology 生物-微生物学

CiteScore

4.10

自引率

3.80%

发文量

审稿时长

16 days

期刊介绍： Research in Microbiology is the direct descendant of the original Pasteur periodical entitled Annales de l''Institut Pasteur, created in 1887 by Emile Duclaux under the patronage of Louis Pasteur. The Editorial Committee included Chamberland, Grancher, Nocard, Roux and Straus, and the first issue began with Louis Pasteur''s "Lettre sur la Rage" which clearly defines the spirit of the journal:"You have informed me, my dear Duclaux, that you intend to start a monthly collection of articles entitled "Annales de l''Institut Pasteur". You will be rendering a service that will be appreciated by the ever increasing number of young scientists who are attracted to microbiological studies. In your Annales, our laboratory research will of course occupy a central position, but the work from outside groups that you intend to publish will be a source of competitive stimulation for all of us."That first volume included 53 articles as well as critical reviews and book reviews. From that time on, the Annales appeared regularly every month, without interruption, even during the two world wars. Although the journal has undergone many changes over the past 100 years (in the title, the format, the language) reflecting the evolution in scientific publishing, it has consistently maintained the Pasteur tradition by publishing original reports on all aspects of microbiology.