Association of placenta weight and morphology with term low birth weight: A case-control study.

IF 1.6 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2025-09-26 eCollection Date: 2025-01-01 DOI:10.1515/med-2025-1264

Jing Liu, Die Liu, Haixiao Liang, Qi Sun, Yuanmei Chen, Fang Ye, Qi Zhang

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引用次数: 0

Abstract

Background and aim: Few studies identified the role of the placenta in birth weight. We aimed to explore the connection between placenta weight, morphology, and term low birth weight (TLBW).

Methods: This was a case-control study of neonates born at ≥37 weeks' gestation enrolled in a general hospital from January 2018 to November 2022. Cases (<2,500 g) identified via birth certificates or medical records were matched with controls on the basis of date of birth, gestational age, sex, and maternal age. A nomogram predictive model was constructed based on logistic regression, using placenta parameters and perinatal information.

Results: A total of 290 neonates (115 with diagnosed TLBW and 175 controls) were determined. There were no significant differences between the two groups concerning gestational age (265.5 ± 5.4 vs 266.3 ± 5.3 days, P = 0.1397), gender, and maternal age at delivery (32.0 ± 3.5 vs 32.1 ± 3.1 years, P = 0.867). The placenta weight (479.0 ± 80.1 vs 597.1 ± 83.1 cm), length (16.3 ± 2.1 vs 18.8 ± 2.0 cm), width (14.3 ± 2.1 vs 16.9 ± 2.0 cm), and thickness (2.3 ± 0.5 vs 2.4 ± 0.4 cm) in the TLBW group were much lower than those in the control group (all P < 0.001). Univariate predictors of TLBW included smaller placental weight, length, width, thickness, volume, and surface area. When put into a multivariate model, placental weight (aOR for per 10 g increase: 0.89; 95% CI: 0.84-0.94) and width (aOR for per 1 cm increase: 0.69; 95% CI: 0.54-0.88) remained to be independent predictors even after controlling for relevant confounders. The odds of TLBW increased when placental weight was below the 50th percentile (aOR: 5.08, 95% CI: 2.59-9.95). Placental width below the 50th percentile was significantly associated with an increased risk of TLBW (aOR: 6.57, 95% CI: 2.73-15.82).

Conclusions: Placental weight and width were found to be associated with TLBW. Further studies focusing on placental function, histology, and pathophysiology are needed to better understand the underlying mechanisms influencing fetal growth and TLBW.

查看原文本刊更多论文

胎盘重量和形态与足月低出生体重的关系：一项病例对照研究。

背景和目的：很少有研究确定胎盘在出生体重中的作用。本研究旨在探讨胎盘重量、形态与足月低出生体重（TLBW）之间的关系。方法：本研究是一项病例对照研究，研究对象为2018年1月至2022年11月在某综合医院登记的≥37周妊娠新生儿。结果：共290例新生儿（确诊TLBW 115例，对照组175例）。两组在胎龄（265.5±5.4 vs 266.3±5.3 d, P = 0.1397）、性别、产妇分娩年龄（32.0±3.5 vs 32.1±3.1岁，P = 0.867）方面差异无统计学意义。TLBW组胎盘重量（479.0±80.1 vs 597.1±83.1 cm）、长度（16.3±2.1 vs 18.8±2.0 cm）、宽度（14.3±2.1 vs 16.9±2.0 cm）、厚度（2.3±0.5 vs 2.4±0.4 cm）均显著低于对照组（P均< 0.001）。TLBW的单变量预测因子包括较小的胎盘重量、长度、宽度、厚度、体积和表面积。当纳入多变量模型时，即使在控制了相关混杂因素后，胎盘重量（每增加10克的aOR: 0.89; 95% CI: 0.84-0.94）和宽度（每增加1厘米的aOR: 0.69; 95% CI: 0.54-0.88）仍然是独立的预测因子。胎盘重量低于50百分位时，TLBW的发生率增加（aOR: 5.08, 95% CI: 2.59 ~ 9.95）。胎盘宽度低于第50百分位与TLBW风险增加显著相关（aOR: 6.57, 95% CI: 2.73-15.82）。结论：胎盘重量和宽度与TLBW有关。需要进一步研究胎盘功能、组织学和病理生理，以更好地了解影响胎儿生长和TLBW的潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.