Mycobiome of Stool, Blood, Thrombus and Vessel Wall in Abdominal Aortic Aneurysm Patients.

IF 2.9 3区 生物学 Q2 MYCOLOGY
Éva Nemes-Nikodém, Gergő Péter Gyurok, Zsuzsanna A Dunai, Nóra Makra, Bálint Hofmeister, Dóra Szabó, László Hidi, Ágnes Szappanos, Gergely Imre Kovács, Péter Sótonyi, Eszter Ostorházi
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Abstract

Abdominal aortic aneurysm (AAA) is a life-threatening vascular condition characterized by inflammatory degeneration of the vessel wall. Emerging evidence suggests that microbial factors contribute to its progression. In this study, we analyzed the mycobiome composition of stool, blood, thrombus and damaged vessel wall samples collected during surgery from 24 AAA patients using Internal Transcribed Spacer (ITS) sequencing. Significant differences in alpha and beta diversity were observed across the sample types, confirming compartmentalization of the mycobiome. However, individual fungal profiles did not establish a clear gut-blood-vessel wall axis, indicating that fungi translocated to the vessel wall may originate from other anatomical regions. Comparison AAA mycobiome with healthy arterial walls' mycobiome from organ donors revealed a dominance of anti-inflammatory Tomentella in healthy samples, while pro-inflammatory Malassezia species were prevalent in damaged vessel walls. These findings highlight the role of fungi in AAA progression and suggest potential thera-peutic avenues, including antifungal adjuvant treatments to mitigate inflammation and aneurysm development.

腹主动脉瘤患者粪便、血液、血栓及血管壁的菌群。
腹主动脉瘤(AAA)是一种危及生命的血管疾病,其特征是血管壁的炎症变性。新出现的证据表明,微生物因素有助于其进展。在这项研究中,我们使用内部转录间隔器(ITS)测序分析了24例AAA患者手术期间收集的粪便、血液、血栓和受损血管壁样本的真菌组组成。在不同的样品类型中观察到α和β多样性的显著差异,证实了真菌群落的区隔化。然而,个别真菌谱并没有建立一个明确的肠道-血管壁轴,这表明真菌易位到血管壁可能起源于其他解剖区域。将AAA菌群与来自器官供体的健康动脉壁的菌群进行比较,发现健康样本中抗炎的托门氏菌占优势,而在受损血管壁中,促炎的马拉色菌普遍存在。这些发现强调了真菌在AAA进展中的作用,并提出了潜在的治疗途径,包括抗真菌辅助治疗,以减轻炎症和动脉瘤的发展。
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来源期刊
Mycopathologia
Mycopathologia 生物-真菌学
CiteScore
6.80
自引率
3.60%
发文量
76
审稿时长
3 months
期刊介绍: Mycopathologia is an official journal of the International Union of Microbiological Societies (IUMS). Mycopathologia was founded in 1938 with the mission to ‘diffuse the understanding of fungal diseases in man and animals among mycologists’. Many of the milestones discoveries in the field of medical mycology have been communicated through the pages of this journal. Mycopathologia covers a diverse, interdisciplinary range of topics that is unique in breadth and depth. The journal publishes peer-reviewed, original articles highlighting important developments concerning medically important fungi and fungal diseases. The journal highlights important developments in fungal systematics and taxonomy, laboratory diagnosis of fungal infections, antifungal drugs, clinical presentation and treatment, and epidemiology of fungal diseases globally. Timely opinion articles, mini-reviews, and other communications are usually invited at the discretion of the editorial board. Unique case reports highlighting unprecedented progress in the diagnosis and treatment of fungal infections, are published in every issue of the journal. MycopathologiaIMAGE is another regular feature for a brief clinical report of potential interest to a mixed audience of physicians and laboratory scientists. MycopathologiaGENOME is designed for the rapid publication of new genomes of human and animal pathogenic fungi using a checklist-based, standardized format.
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