Supplement strategies for infertility in overweight women: Evidence and legal insights.

IF 1.6 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2025-09-25 eCollection Date: 2025-01-01 DOI:10.1515/med-2025-1293

Giuseppe Gullo, Eleonora Conti, Valentina Billone, Elena Chitoran, Karolina Kowalcze, Robert Krysiak, Alberto Vaiarelli, Romualdo Sciorio, Stamatios Petousis, Yuliia Kotlik, Antonio Perino, Gaspare Cucinella, Susanna Marinelli, Lina De Paola

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引用次数: 0

Abstract

Background: Infertility is a multifactorial condition that affects both men and women and is influenced by various factors, including overweight and obesity. These conditions, especially in women with polycystic ovary syndrome (PCOS), are strongly associated with hormonal and metabolic imbalances that can impair fertility. Targeted nutritional interventions, such as nutraceutical supplementation, may offer support in improving reproductive outcomes.

Methods: A narrative review was conducted using PubMed, focusing on publications from the past 12 years with the keywords "nutraceutical," "overweight," and "infertility." The review aimed to identify the main nutraceuticals used in managing infertility and to highlight the importance of a personalized approach tailored to individual patient characteristics.

Results: Nutraceuticals may represent a safe and cost-effective adjunctive strategy to support fertility in overweight patients, particularly in those with PCOS. Evidence suggests that their effectiveness increases when integrated into a personalized treatment plan based on individual needs and clinical profiles.

Conclusions: This review offers an updated overview of nutraceutical use in overweight individuals with infertility, outlining both benefits and limitations. It also addresses the often-overlooked medico-legal aspects of prescribing nutraceuticals, emphasizing the need for ethical and legal awareness when incorporating these interventions into clinical practice.

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超重妇女不孕的补充策略：证据和法律见解。

背景：不孕症是一种多因素的疾病，男性和女性都有可能受到多种因素的影响，包括超重和肥胖。这些情况，尤其是患有多囊卵巢综合征（PCOS）的女性，与激素和代谢失衡密切相关，从而损害生育能力。有针对性的营养干预措施，如营养补充剂，可能有助于改善生殖结果。方法：使用PubMed进行叙述性回顾，重点关注过去12年以“营养”、“超重”和“不育”为关键词的出版物。本综述旨在确定用于治疗不孕症的主要营养保健品，并强调针对个体患者特征量身定制个性化方法的重要性。结果：营养药品可能是一种安全且经济有效的辅助策略，以支持超重患者的生育能力，特别是那些患有多囊卵巢综合征的患者。有证据表明，当将其纳入基于个人需求和临床概况的个性化治疗计划时，其有效性会提高。结论：本综述提供了营养保健品在超重不孕症患者中使用的最新概况，概述了其益处和局限性。它还涉及开营养品处方时经常被忽视的医学法律方面，强调在将这些干预措施纳入临床实践时需要有道德和法律意识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.