To improve outcome after ovarian tissue cryopreservation and transplantation: Clinical approach based on a case series and literature review

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-10-02 DOI:10.1111/jog.70080

Hannah R. Rowling, Lucette A. J. van der Westerlaken, Eileen E. L. O. Lashley

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引用次数: 0

Abstract

Aim

Ovarian tissue cryopreservation (OTC) is an acceptable fertility preservation technique in prepubertal girls and those unable to undergo ovarian stimulation for oocyte vitrification. Currently, there is limited data regarding the optimal fertility approach within this patient population. We aimed to determine a protocol for clinicians to help patients that underwent postpubertal OTC and return with the wish to conceive.

Methods

In this study, we describe the management and outcome of 14 patients that underwent OTC and ovarian tissue transplantation (OTT) in our tertiary center and review the existing literature on management and outcome after OTC and OTT.

Results

Our findings suggest pregnancy chances after OTT are highest in patients <36 years of age, with normal ovarian reserve at the time of OTC, who have not received radiotherapy to the pelvic area. Chances of pregnancy after heterotopic transplantation are low. Assisted reproductive technology (ART) outcomes after OTT are lower than in the general population with subfertility.

Conclusions

A passive ART approach is advised after OTT, except in patients with pre-existing fertility issues. For others, ART can be considered if pregnancy is not achieved within 10 months after ovarian function recovery. Repeated transplantation has limited efficacy and should be carefully considered, especially in those who did not regain ovarian function after first OTT.

Abstract Image

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改善卵巢组织冷冻保存和移植后的预后：基于病例系列和文献回顾的临床方法。

目的：卵巢组织冷冻保存（OTC）是一种可接受的保存生育能力的技术在青春期前的女孩和那些不能接受卵巢刺激卵母细胞玻璃化。目前，关于这一患者群体的最佳生育方法的数据有限。我们的目的是为临床医生确定一个方案，以帮助那些接受青春期后OTC治疗并怀着怀孕愿望返回的患者。方法：在本研究中，我们描述了14例在我们三级中心接受OTC和卵巢组织移植（OTT）的患者的处理和结果，并回顾了现有的关于OTC和OTT后的处理和结果的文献。结果：我们的研究结果表明，体外受精后患者的怀孕几率最高。结论：体外受精后，除了存在生育问题的患者外，建议采用被动抗逆转录病毒治疗。对于其他人，如果在卵巢功能恢复后10个月内未怀孕，则可以考虑ART。反复移植的效果有限，应慎重考虑，特别是首次卵巢移植后未恢复卵巢功能的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.