Prevalence of alloantibodies among antenatal women attending a teaching hospital in central Kerala.

IF 1 Q4 PRIMARY HEALTH CARE
Rose Mary Jacob Vatakencherry, Susan John, Veena Shenoy, L Saraswathy
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Abstract

Introduction: Rh immunoprophylaxis has helped to decrease the prevalence of Rh D associated Haemolytic disease of New-born and Foetus. 50 different RBC antigens have been reported to be associated with HDFN. The current incidence of alloimmunization due to non-RhD antibodies in Western countries is 0.28-0.33%. A study on 707 neonates showed antigen-positivity and evidence of HDFN in 37%, with the most severe with DAT-positive anti-Rh antibodies, C, D, e, E. Early detection, monitoring, and planned interventions would help to prevent severe HDFN.

Materials and methods: The Study included 370 pregnant women attending the antenatal clinic of our hospital and excluded those with a history of transfusion, haemolytic disease, intrauterine bleeding or intrauterine death. Irregular antibodies were checked by the Indirect Coombs Test (ICT) using ID Diacell I-II-III, Diamed, Switzerland. Specific antibody identification was performed using ID Diapanel, Diamed, Switzerland.

Statistical analysis: Statistical analysis was done using IBM SPSS Statistics 20.0. Pearson's Chi-square test was applied. Odds ratio and their 95% CI were calculated.

Results: Red cell antibody screening was positive in 3.5% (13). Antibodies identified as anti-D (30.8%), anti-c (15.4%), anti-C + D (15.4%), anti-K (15.4%), anti-Le b + Jka (7.7%), anti-E (7.7%), and anti-c + Jka (7.7%).

Conclusion: The maternal alloimmunization prevalence was 3.5%. The potential for severe HDFN associated with antibodies such as anti-K, anti-E, and anti-c necessitates vigilant monitoring at the primary care level.

Abstract Image

Abstract Image

喀拉拉邦中部一家教学医院产前妇女同种异体抗体的流行
Rh免疫预防有助于降低新生儿和胎儿Rh - D相关溶血性疾病的患病率。已有50种不同的RBC抗原被报道与HDFN相关。目前西方国家因非rhd抗体引起的同种异体免疫发生率为0.28-0.33%。一项对707名新生儿的研究显示抗原阳性,37%的新生儿有HDFN的证据,最严重的是dat阳性的抗rh抗体,C, D, e, e。早期发现,监测和有计划的干预将有助于预防严重的HDFN。材料与方法:本研究纳入我院产前门诊370例孕妇,排除有输血史、溶血性疾病史、宫内出血史、宫内死亡史的孕妇。使用ID Diacell I-II-III, Diamed, Switzerland进行间接库姆试验(ICT)检测不规则抗体。特异性抗体鉴定使用ID Diapanel, Diamed,瑞士。统计分析:采用IBM SPSS Statistics 20.0进行统计分析。采用Pearson卡方检验。计算优势比及其95% CI。结果:红细胞抗体筛查阳性率为3.5%(13)。抗体鉴定为抗D(30.8%)、抗c(15.4%)、抗c + D(15.4%)、抗k(15.4%)、抗le b + Jka(7.7%)、抗e(7.7%)、抗c + Jka(7.7%)。结论:产妇同种异体免疫率为3.5%。与抗k、抗e和抗c等抗体相关的严重hdn的可能性需要在初级保健水平进行警惕监测。
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自引率
7.10%
发文量
884
审稿时长
40 weeks
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