Peripheral inflammation in spinocerebellar ataxia type 3: associations with genetic and clinical manifestations.

IF 5.4 3区医学 Q2 CELL BIOLOGY

Inflammation Research Pub Date : 2025-10-03 DOI:10.1007/s00011-025-02102-8

Jia-Yi Zhang, Qiu-Ni Su, Han Lin, Wei Lin, Mao-Lin Cui, Zhuo-Ying Huang, Bei-Ning Ye, Ying-Xin Ye, Yi-Lin Jia, Qing-Ying Zhu, Zhi-Han Li, Min-Ting Lin, Ning Wang, Bing-Long Wang, Shi-Rui Gan

{"title":"Peripheral inflammation in spinocerebellar ataxia type 3: associations with genetic and clinical manifestations.","authors":"Jia-Yi Zhang, Qiu-Ni Su, Han Lin, Wei Lin, Mao-Lin Cui, Zhuo-Ying Huang, Bei-Ning Ye, Ying-Xin Ye, Yi-Lin Jia, Qing-Ying Zhu, Zhi-Han Li, Min-Ting Lin, Ning Wang, Bing-Long Wang, Shi-Rui Gan","doi":"10.1007/s00011-025-02102-8","DOIUrl":null,"url":null,"abstract":"Background: Neuroinflammation plays a recognized role in the pathogenesis of Spinocerebellar Ataxia Type 3 (SCA3). However, the involvement of systemic inflammatory responses in SCA3 remains poorly defined.Objectives: Our study aimed to characterize peripheral inflammation in patients with SCA3, examine the relationship between peripheral inflammatory biomarkers and clinical/genetic features, and evaluate the diagnostic utility of these markers.Methods: The cross-sectional study enrolled 101 patients with SCA3 and 101 healthy controls (HCs). The differences in peripheral inflammatory markers between patients with SCA3 and HCs were assessed. Multivariate linear regressions were used to analyze the associations between blood cell count-derived indices, C-reactive protein (CRP), and clinical/genetic features of SCA3. ROC curves were conducted to assess the potential of these markers to distinguish patients with SCA3 from HCs.Results: Compared to HCs, patients with SCA3 exhibited significantly higher levels of leukocytes, neutrophils, monocytes, platelets, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), systemic inflammatory index (SII), systemic inflammatory composite index (AISI), and CRP (adj. p < 0.05). Age influenced lgCRP, NLR, MLR, and lg(neutrophil-to-platelet ratio) (p < 0.05). CAG affected MLR and AISI (p < 0.05). The combination of BMI, monocytes, NLR, and SII differentiated patients with SCA3 from HCs (AUC = 0.779).Conclusion: Patients with SCA3 display distinct peripheral inflammatory profiles, which correlate with clinical/genetic factors. These peripheral inflammatory markers hold promise as potential tools for diagnosing and monitoring SCA3.","PeriodicalId":13550,"journal":{"name":"Inflammation Research","volume":"74 1","pages":"137"},"PeriodicalIF":5.4000,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inflammation Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00011-025-02102-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Neuroinflammation plays a recognized role in the pathogenesis of Spinocerebellar Ataxia Type 3 (SCA3). However, the involvement of systemic inflammatory responses in SCA3 remains poorly defined.

Objectives: Our study aimed to characterize peripheral inflammation in patients with SCA3, examine the relationship between peripheral inflammatory biomarkers and clinical/genetic features, and evaluate the diagnostic utility of these markers.

Methods: The cross-sectional study enrolled 101 patients with SCA3 and 101 healthy controls (HCs). The differences in peripheral inflammatory markers between patients with SCA3 and HCs were assessed. Multivariate linear regressions were used to analyze the associations between blood cell count-derived indices, C-reactive protein (CRP), and clinical/genetic features of SCA3. ROC curves were conducted to assess the potential of these markers to distinguish patients with SCA3 from HCs.

Results: Compared to HCs, patients with SCA3 exhibited significantly higher levels of leukocytes, neutrophils, monocytes, platelets, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), systemic inflammatory index (SII), systemic inflammatory composite index (AISI), and CRP (adj. p < 0.05). Age influenced lgCRP, NLR, MLR, and lg(neutrophil-to-platelet ratio) (p < 0.05). CAG affected MLR and AISI (p < 0.05). The combination of BMI, monocytes, NLR, and SII differentiated patients with SCA3 from HCs (AUC = 0.779).

Conclusion: Patients with SCA3 display distinct peripheral inflammatory profiles, which correlate with clinical/genetic factors. These peripheral inflammatory markers hold promise as potential tools for diagnosing and monitoring SCA3.

查看原文本刊更多论文

脊髓小脑性共济失调3型的外周炎症：与遗传和临床表现的关系

背景：神经炎症在脊髓小脑性共济失调3型（SCA3）的发病机制中起着公认的作用。然而，全身炎症反应在SCA3中的参与仍然不明确。目的：我们的研究旨在表征SCA3患者的外周炎症，检查外周炎症生物标志物与临床/遗传特征之间的关系，并评估这些标志物的诊断效用。方法：横断面研究纳入101例SCA3患者和101例健康对照（hc）。评估SCA3和hc患者外周血炎症标志物的差异。采用多变量线性回归分析血细胞计数指标、c反应蛋白（CRP）与SCA3临床/遗传特征之间的关系。采用ROC曲线来评估这些标记物区分SCA3患者和hc患者的潜力。结果：与hcc患者相比，SCA3患者的白细胞、中性粒细胞、单核细胞、血小板、中性粒细胞与淋巴细胞比值（NLR）、单核细胞与淋巴细胞比值（MLR）、全身炎症指数（SII）、全身炎症综合指数（AISI）和CRP水平显著升高。结论：SCA3患者表现出明显的外周炎症特征，这与临床/遗传因素有关。这些外周炎症标志物有望成为诊断和监测SCA3的潜在工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Inflammation Research 医学-免疫学

CiteScore

9.90

自引率

1.50%

发文量

134

审稿时长

3-8 weeks

期刊介绍： Inflammation Research (IR) publishes peer-reviewed papers on all aspects of inflammation and related fields including histopathology, immunological mechanisms, gene expression, mediators, experimental models, clinical investigations and the effect of drugs. Related fields are broadly defined and include for instance, allergy and asthma, shock, pain, joint damage, skin disease as well as clinical trials of relevant drugs.