The effect of resistance training on physical function is associated with changes in serum albumin redox state in middle-aged and older Japanese adults: a Quasi-experimental study.

IF 3.2 3区医学 Q2 PHYSIOLOGY

Frontiers in Physiology Pub Date : 2025-09-17 eCollection Date: 2025-01-01 DOI:10.3389/fphys.2025.1649300

Takuya Shibasaki, Hirohiko Nakamura, Yuka Kurosaka, Shuji Sawada, Kazuhiro Miyaji, Shuichi Machida

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引用次数: 0

Abstract

Background: Resistance training is important for improving physical function in middle-aged and older adults. The fraction of mercaptoalbumin in total serum albumin, represented as f(HMA), is an indicator of physical function and protein nutritional status in humans. However, it is unclear whether the effects of resistance training on physical function are associated with changes in f(HMA). This study was aimed at examining the relationship between f(HMA) and the effects of resistance training in healthy middle-aged and older Japanese adults.

Methods: The study included 43 healthy community dwelling middle-aged and elderly individuals (10 males and 33 females, aged 67.3 ± 8.0 years). They were engaged in a low-load, body-weight-based resistance training program using an elastic band twice a week for 12 weeks under supervision. Anthropometric data, 6-meter gait speed, blood biochemistry, and dietary macronutrient intake were collected before and after the training intervention. The relationships between serum nutritional parameters and gait speed or their rate of change were examined using multivariate linear regression analysis.

Results: Before intervention, f(HMA) showed a significant positive correlation with the usual (β = 0.326, P = 0.045) and maximum (β = 0.331, P = 0.036) gait speeds. The changing rate of maximal gait speed showed a significant positive correlation with the rate of increase in f(HMA) (β = 0.456, P = 0.004).

Conclusion: Serum f(HMA) increased with improvements in physical function through resistance training in middle-aged and older adults.

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抗阻训练对身体机能的影响与日本中老年成人血清白蛋白氧化还原状态的变化有关：一项准实验研究。

背景：抗阻训练对改善中老年人身体机能具有重要意义。巯基白蛋白在总血清白蛋白中的比例，用f（HMA）表示，是人类身体功能和蛋白质营养状况的指标。然而，目前尚不清楚阻力训练对身体功能的影响是否与f（HMA）的变化有关。本研究旨在探讨f（HMA）与日本健康中老年人抗阻训练效果之间的关系。方法：纳入43例健康社区居住中老年人，其中男性10例，女性33例，年龄67.3±8.0岁。他们在监督下进行了一项低负荷、以体重为基础的阻力训练计划，每周两次使用橡皮筋，持续12周。在训练干预前后收集人体测量数据、6米步速、血液生化和饮食常量营养素摄入量。采用多元线性回归分析检测血清营养参数与步态速度或其变化率之间的关系。结果：干预前，f（HMA）与常步速（β = 0.326, P = 0.045）、最大步速（β = 0.331, P = 0.036）呈显著正相关。最大步速变化率与f（HMA）升高率呈显著正相关（β = 0.456, P = 0.004）。结论：中老年人群抗阻训练后血清f（HMA）随身体机能的改善而升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Physiology PHYSIOLOGY-

CiteScore

6.50

自引率

5.00%

发文量

2608

审稿时长

14 weeks

期刊介绍： Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. Field Chief Editor George E. Billman at the Ohio State University Columbus is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.