From biofilm control to biomimetic remineralization: Hydrogels in prevention and treatment of dental caries.

IF 4.8 2区医学 Q2 IMMUNOLOGY

Frontiers in Cellular and Infection Microbiology Pub Date : 2025-09-17 eCollection Date: 2025-01-01 DOI:10.3389/fcimb.2025.1663563

Yuqing Chen, Shikang Lin, Xiaojing Huang, Wen Zhou

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Abstract

Dental caries, a prevalent chronic bacterial disease globally, poses a significant threat to public health due to its complex pathogenesis involving demineralization and microbial dysbiosis. Hydrogels, with their unique three-dimensional network structures and diverse properties, have shown great potential in prevention and treatment of dental caries. This article systematically reviews recent advances in anti-caries hydrogel development. It first introduces the basis of anti-caries hydrogels, covering the applications of natural and semi-synthetic polymers as hydrogel matrices. Then, it elaborates on the mechanisms and research status of different types of anti-caries hydrogels, including probiotic formulations, antibacterial hydrogels, remineralization-inducing hydrogels, and saliva-related caries-reducing hydrogels. Finally, it summarizes the current research achievements and limitations and looks ahead to future research directions.

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从生物膜控制到仿生再矿化：水凝胶预防和治疗龋齿。

龋齿是一种全球性的慢性细菌性疾病，由于其复杂的发病机制涉及脱矿和微生物生态失调，对公众健康构成重大威胁。水凝胶以其独特的三维网状结构和多样的特性，在预防和治疗龋齿方面显示出巨大的潜力。本文系统地综述了近年来抗龋水凝胶的研究进展。首先介绍了抗龋水凝胶的基础，涵盖了天然和半合成聚合物作为水凝胶基质的应用。然后，阐述了不同类型的抗龋水凝胶的作用机理和研究现状，包括益生菌制剂、抗菌水凝胶、诱导再矿化水凝胶和与唾液相关的减龋水凝胶。最后，总结了目前的研究成果和局限性，并展望了未来的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cellular and Infection Microbiology IMMUNOLOGY-MICROBIOLOGY

CiteScore

7.90

自引率

7.00%

发文量

1817

审稿时长

14 weeks

期刊介绍： Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.