Dapsone 7.5% Gel Versus Trichloroacetic Acid Peels.

IF 2.2 3区医学 Q2 DERMATOLOGY

Dermatologic Surgery Pub Date : 2025-10-03 DOI:10.1097/DSS.0000000000004896

Dalia A Atallah, Sahar R Bestawy, Sara A Abouelmajd, Aya Y Badran

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引用次数: 0

Abstract

Background: Acne vulgaris is a chronic and multifactorial skin disease that can occur during adulthood, with a negative impact on self-esteem. Dapsone is a common antibacterial and anti-inflammatory medication used to treat several skin conditions.

Objective: Objectives were to compare efficacy, tolerability, and safety of dapsone 7.5% gel versus trichloroacetic acid peel TCA 20% in the treatment of acne vulgaris.

Materials and methods: Thirty patients with acne vulgaris participated in a split-face, comparative, quasi-experimental clinical study. Trichloroacetic acid peels 20% were applied to the right side of the participants' face every 2 weeks for 3 months. The participants were instructed to apply dapsone 7.5% gel once daily at night on the left side of the face for 3 months.

Results: There was a little difference between the 2 treatments; however, both sides of the face showed a considerable decrease in lesion counts and the Global Acne Grading Score (GAGS) after treatment.

Conclusion: The clinical effectiveness of trichloroacetic acid peeling and dapsone 7.5% gel was not significantly different in mild and moderate acne vulgaris. Dapsone 7.5% gel is more effective in treating inflammatory than noninflammatory lesions.

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7.5%氨苯砜凝胶与三氯乙酸脱皮。

背景：寻常痤疮是一种慢性多因素皮肤病，可发生在成年期，对自尊有负面影响。氨苯砜是一种常见的抗菌和消炎药，用于治疗几种皮肤状况。目的：比较7.5%氨苯砜凝胶与20%三氯乙酸脱皮TCA治疗寻常性痤疮的疗效、耐受性和安全性。材料与方法：对30例寻常性痤疮患者进行裂脸、比较性、准实验性临床研究。每两周将20%的三氯乙酸换肤剂涂抹在受试者的右侧面部，持续3个月。参与者被要求每天晚上在左侧面部涂抹一次7.5%的氨苯砜凝胶，持续3个月。结果：两种治疗间差异不大；然而，治疗后，两侧面部的病变计数和总体痤疮评分（GAGS）均显著下降。结论：三氯乙酸脱皮与7.5%氨苯砜凝胶治疗轻、中度寻常痤疮的临床疗效无显著性差异。7.5%氨苯砜凝胶治疗炎性病变比非炎性病变更有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatologic Surgery 医学-皮肤病学

CiteScore

3.10

自引率

16.70%

发文量

547

期刊介绍： Exclusively devoted to dermatologic surgery, the Dermatologic Surgery journal publishes the most clinically comprehensive and up-to-date information in its field. This unique monthly journal provides today’s most expansive and in-depth coverage of cosmetic and reconstructive skin surgery and skin cancer through peer-reviewed original articles, extensive illustrations, case reports, ongoing features, literature reviews and correspondence. The journal provides information on the latest scientific information for all types of dermatologic surgery including: -Ambulatory phlebectomy- Blepharoplasty- Body contouring- Chemical peels- Cryosurgery- Curettage and desiccation- Dermabrasion- Excision and closure- Flap Surgery- Grafting- Hair restoration surgery- Injectable neuromodulators- Laser surgery- Liposuction- Microdermabrasion- Microlipoinjection- Micropigmentation- Mohs micrographic surgery- Nail surgery- Phlebology- Sclerotherapy- Skin cancer surgery- Skin resurfacing- Soft-tissue fillers. Dermatologists, dermatologic surgeons, plastic surgeons, oculoplastic surgeons and facial plastic surgeons consider this a must-read publication for anyone in the field.