{"title":"Guillain-Barré Syndrome Mimicking Autoimmune Hepatitis: A Rare Entity.","authors":"Ibrahim Abdelmotelib, Dauris Rosario Lora, Omar Abdelhalim, Hazem Abosheaishaa, Sheila Eswaran, Nancy Reau","doi":"10.14309/crj.0000000000001842","DOIUrl":null,"url":null,"abstract":"<p><p>This case report describes a rare association between autoimmune hepatitis (AIH) and Guillain-Barré syndrome. A 71-year-old woman with a history of hypertension, diabetes, and hyperlipidemia presented with elevated liver enzymes and progressive distal limb weakness. Electromyography confirmed acute motor axonal neuropathy, a variant of Guillain-Barré syndrome, without an identifiable trigger. Serologies for viral hepatitis were negative; however, autoantibodies, including antinuclear antibody, antimitochondrial antibody, and smooth muscle antibody, were positive. Liver biopsy demonstrated histopathologic features consistent with AIH, although typical clinical symptoms of AIH were not apparent. The patient's liver enzymes normalized after treatment with intravenous immunoglobulin. Further investigation into this uncommon clinical association is warranted.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 10","pages":"e01842"},"PeriodicalIF":0.5000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487907/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACG Case Reports Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14309/crj.0000000000001842","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This case report describes a rare association between autoimmune hepatitis (AIH) and Guillain-Barré syndrome. A 71-year-old woman with a history of hypertension, diabetes, and hyperlipidemia presented with elevated liver enzymes and progressive distal limb weakness. Electromyography confirmed acute motor axonal neuropathy, a variant of Guillain-Barré syndrome, without an identifiable trigger. Serologies for viral hepatitis were negative; however, autoantibodies, including antinuclear antibody, antimitochondrial antibody, and smooth muscle antibody, were positive. Liver biopsy demonstrated histopathologic features consistent with AIH, although typical clinical symptoms of AIH were not apparent. The patient's liver enzymes normalized after treatment with intravenous immunoglobulin. Further investigation into this uncommon clinical association is warranted.
期刊介绍：
ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
