Prenatal exposure to acrylamide, fetal growth and newborn size: A biomarker-based cohort study from Denmark.

IF 7.7 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Research Pub Date : 2025-09-30 DOI:10.1016/j.envres.2025.122996

Damian Chandia-Poblete , Stéphane Tuffier , Efstathios Vryonidis , Thorhallur Ingi Halldorsson , Anne Ahrendt Bjerregaard , Dorte Rytter , Bodil Hammer Bech , Tine Brink Henriksen , Sjurdur Frodi Olsen , Margareta Törnqvist , Marie Pedersen

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引用次数: 0

Abstract

Background

Acrylamide (AA) from diet in pregnancy has been associated with reduced birth weight (BW), but the impact on fetal size is unknown.

Objectives

To assess prenatal exposure to AA and associations with fetal size and size at birth.

Methods

Prenatal exposure to AA was measured using a high-throughput method evaluating hemoglobin adducts from AA (HbAA) and glycidamide (HbGA) in blood from pregnant women participating in the Danish Fetal Origins 1988-89 cohort (N = 991). Associations between HbAA and clinical records of fetal growth restriction (clinician-based FGR), biparietal diameter (BPD) at 16 gestational weeks, and small-for-gestational-age (SGA), BW, birth head circumference (BHC) and birth length (BL) were evaluated in the full population and after stratification by maternal smoking during pregnancy in multivariable models.

Results

Maternal HbAA median (5th-95th percentile) was 92 (45–264) pmol/g Hb and active smoking was common (42 %). Higher levels of HbAA were associated with non-significant smaller BPD. Compared to the lowest quartile, the highest quartile of HbAA was associated with a higher odds ratio of 4.00; 95 % confidence interval (CI; 1.23, 16.00) for clinician-based FGR and of 4.03 (95 %CI 1.46, 13.16) for SGA and a mean reduction in BW of 292 g (95 %CI -423, −161). Each 10-pmol/g Hb increase in HbAA was associated with a smaller offspring size at birth: 11 g (95 %CI -18, −5) for BW, −0.05 cm (−0.09, −0.01) for BHC, and −0.03 cm (−0.07, −0.01) for BL. These associations were evident after adjustment for smoking, but not in the smaller subsets of nonsmokers (n = 366) or subjects with HbGA measurement (n = 280).

Conclusion

This biomarker-based cohort study provides new evidence of an increase in the risk of clinician-based FGR, a critical indicator of long-term health, following prenatal exposure to AA. Furthermore, our findings add to the existing evidence that prenatal exposure to AA are associated with reduced newborn size at birth and call for more research on the effects of exposure to AA early in fetal growth and development.

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产前丙烯酰胺暴露、胎儿生长和新生儿大小：丹麦一项基于生物标志物的队列研究。

背景：妊娠期饮食中的丙烯酰胺（AA）与出生体重（BW）降低有关，但对胎儿大小的影响尚不清楚。目的：评估产前暴露于AA及其与胎儿大小和出生时大小的关系。方法：采用高通量方法评估1988-89年丹麦胎儿起源队列（N=991）孕妇血液中AA （HbAA）和甘油酰胺（HbGA）的血红蛋白加合物，测量产前AA暴露情况。HbAA与胎儿生长受限（临床基础FGR）、16孕周时双顶径（BPD）、小胎龄（SGA）、BW、出生头围（BHC）和出生长（BL）的临床记录之间的关系在多变量模型中进行了评估。结果：产妇HbAA中位数（第5- 95百分位）为92 (45-264)pmol/g Hb，吸烟常见（42%）。较高的HbAA水平与较小的BPD无关。与最低四分位数相比，HbAA最高四分位数的优势比为4.00；临床FGR的95%可信区间为1.23,16.00，SGA的95%可信区间为4.03 (95%CI 1.46, 13.16)，平均体重减少292 g （95%CI -423, -161）。HbAA每增加10 pmol/g Hb与出生时的后代尺寸较小相关：BW为-11 g (95%CI -18, -5)， BHC为-0.05 cm (-0.09, -0.01)， BL为-0.03 cm（-0.07, -0.01）。这些关联在吸烟调整后很明显，但在较小的非吸烟者亚群（n=366）或HbGA测量对象（n=280）中不明显。结论：这项基于生物标志物的队列研究提供了新的证据，证明产前暴露于AA后，临床基于FGR（长期健康的关键指标）的风险增加。此外，我们的研究结果补充了现有的证据，即产前暴露于AA与出生时体重减少有关，并呼吁对胎儿生长发育早期暴露于AA的影响进行更多的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Research 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

12.60

自引率

8.40%

发文量

2480

审稿时长

4.7 months

期刊介绍： The Environmental Research journal presents a broad range of interdisciplinary research, focused on addressing worldwide environmental concerns and featuring innovative findings. Our publication strives to explore relevant anthropogenic issues across various environmental sectors, showcasing practical applications in real-life settings.