2-Formylphenylboronic acid functionalized B, N co-doped carbon dots for glucose sensor by the fluorescence turn off process

IF 2.6 4区材料科学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Nanoparticle Research Pub Date : 2025-10-03 DOI:10.1007/s11051-025-06460-6

Jiayi Luo, Taixian Wang, Wen Guo, Jiaxin Xu, Muting Zheng, Danying Zuo, Hongwei Zhang

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Abstract

In this work, we developed a novel fluorescent glucose sensor based on boron and nitrogen co-doped carbon dots (BN-CDs) functionalized with 2-formylphenylboronic acid (2-FPBA) via a facile one-step hydrothermal synthesis followed by condensation grafting. The resulting BN-CD/2-FPBA nanocomposite exhibits excellent water solubility, high fluorescence stability, and superior selectivity toward glucose through a turn-off fluorescence mechanism. Unlike conventional enzyme-based or heavy-metal-containing quantum dot sensors, our system leverages the intrinsic Lewis acid properties of B atoms and the synergistic effects of B, N co-doping to achieve specific glucose recognition with minimal interference from common biomolecules and ions. The sensor demonstrates a wide linear detection range of 100–4000 μM and a low detection limit of 77.17 μM. This work not only presents a robust, enzyme-free platform for glucose monitoring but also offers a generalizable functionalization strategy for designing high-performance carbon dot-based biosensors.

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2-甲酰苯硼酸功能化B， N共掺杂碳点用于葡萄糖传感器的荧光关闭过程

在这项工作中，我们开发了一种基于硼氮共掺杂碳点（BN-CDs）的新型荧光葡萄糖传感器，该碳点被2-甲酰苯基硼酸（2-FPBA）功能化，通过简单的一步水热合成和缩合接枝。得到的BN-CD/2-FPBA纳米复合材料具有优异的水溶性，高荧光稳定性，并通过关闭荧光机制对葡萄糖具有优越的选择性。与传统的基于酶或含重金属的量子点传感器不同，我们的系统利用B原子固有的刘易斯酸特性和B、N共掺杂的协同效应，在最小的生物分子和离子干扰下实现特定的葡萄糖识别。该传感器具有100 ~ 4000 μM的宽线性检测范围和77.17 μM的低检测限。这项工作不仅为葡萄糖监测提供了一个强大的无酶平台，而且为设计高性能碳点生物传感器提供了一种通用的功能化策略。

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来源期刊

Journal of Nanoparticle Research 工程技术-材料科学：综合

CiteScore

4.40

自引率

4.00%

发文量

198

审稿时长

3.9 months

期刊介绍： The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size. Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology. The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.