Preparation of a nanodiamond suspension with immobilized lutetium-177 and study of its biodistribution

IF 1.6 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2025-08-21 DOI:10.1007/s10967-025-10326-5

Andrey G. Kazakov, Daria V. Pavlova, Taisia Y. Ekatova, Maria S. Larkina, Ruslan N. Varvashenya, Gleb E. Yanovich, Evgenii V. Plotnikov, Ivan A. Ushakov, Evgeny A. Nesterov, Valery V. Zukau, Sergey E. Vinokurov

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Abstract

Nanodiamonds (ND) were studied as nanosized carriers of medical isotope ¹⁷⁷Lu. Conditions for preparation of a ND suspension with immobilized ¹⁷⁷Lu in solutions which meet the requirements for intravenous administration of radiopharmaceuticals based on medical isotope ¹⁷⁷Lu were determined. The possibility of quantitative bonding of lutetium with ND in isotonic solutions which have necessary pH and minimal amount of ND was demonstrated. The parameters of Freundlich and Langmuir adsorption isotherms and thermodynamic parameters of adsorption in optimal conditions for the most promising sample of ND were calculated. In vivo experiments for determination of biodistribution of ¹⁷⁷Lu labeled ND in CD1 mice 4 and 48 h after intravenous injection were conducted. The highest percentage of isotope accumulation was observed in liver and spleen, and these values did not significantly decrease after 48 h; the increased accumulation in bone tissue was also detected. It was noted that ¹⁷⁷Lu sorbed onto ND can be promisingly injected directly into tumor for therapy.

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固定化镥-177纳米金刚石悬浮液的制备及其生物分布研究

研究了纳米金刚石（ND）作为医用同位素177Lu的纳米载体。以医用同位素177Lu为基础，确定了在满足静脉给药要求的溶液中固定化177Lu制备ND混悬液的条件。在一定pH值和微量ND的等渗溶液中，证明了镥与ND定量成键的可能性。计算了最有前途的ND样品在最佳条件下的Freundlich和Langmuir吸附等温线参数和吸附热力学参数。在CD1小鼠体内进行静脉注射后4和48 h的生物分布实验。肝脏和脾脏的同位素积累率最高，48h后这些数值没有显著下降；还检测到骨组织中积累量增加。结果表明，吸附在ND上的177Lu有望直接注射到肿瘤中进行治疗。

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.