{"title":"Applications of DNA origami in biomedicine: advances, challenges, and prospects","authors":"Ruipeng Chen, Xuexia Jia, Wei Pang, Yingao Yang, Huanying Zhou, Zhixian Gao","doi":"10.1007/s42114-025-01457-0","DOIUrl":null,"url":null,"abstract":"<div><p>DNA serves as a fundamental carrier of genetic information, and its unique properties allow it to be used as a versatile structural component for the engineering and self-assembly of nanostructures. The advent of DNA templates has significantly improved self-assembled DNA nanostructures, and this progress is particularly evident in the field of DNA nanotechnology, especially in DNA origami, which is highly effective for the bottom-up synthesis of precisely defined nanostructures that range in size from tens of nanometers to sub-micrometers. The remarkable capabilities of DNA origami open up numerous possibilities in the context of biomedical applications. These applications include drug delivery systems, vaccine development, tissue engineering, targeted disease therapies, clinical diagnostics, and advanced bioimaging techniques. This review highlights the significance and benefits of employing DNA origami in the programming and fabrication of DNA nanostructures, showcasing its potential impacts in various domains. The challenges associated with DNA nanotechnology are also examined, and possible solutions are considered to facilitate advancements in the field. Furthermore, a comprehensive overview of the current and potential biomedical applications of DNA origami is presented. The review concludes with reflections on the future perspectives of DNA origami, highlighting its importance and potential growth in various scientific and medical fields.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 5","pages":""},"PeriodicalIF":21.8000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01457-0.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Composites and Hybrid Materials","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s42114-025-01457-0","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, COMPOSITES","Score":null,"Total":0}
引用次数: 0
Abstract
DNA serves as a fundamental carrier of genetic information, and its unique properties allow it to be used as a versatile structural component for the engineering and self-assembly of nanostructures. The advent of DNA templates has significantly improved self-assembled DNA nanostructures, and this progress is particularly evident in the field of DNA nanotechnology, especially in DNA origami, which is highly effective for the bottom-up synthesis of precisely defined nanostructures that range in size from tens of nanometers to sub-micrometers. The remarkable capabilities of DNA origami open up numerous possibilities in the context of biomedical applications. These applications include drug delivery systems, vaccine development, tissue engineering, targeted disease therapies, clinical diagnostics, and advanced bioimaging techniques. This review highlights the significance and benefits of employing DNA origami in the programming and fabrication of DNA nanostructures, showcasing its potential impacts in various domains. The challenges associated with DNA nanotechnology are also examined, and possible solutions are considered to facilitate advancements in the field. Furthermore, a comprehensive overview of the current and potential biomedical applications of DNA origami is presented. The review concludes with reflections on the future perspectives of DNA origami, highlighting its importance and potential growth in various scientific and medical fields.
期刊介绍：
Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field.
The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest.
Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials.
Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.
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