Robust self-pumping medical microneedle arrays by nanofiber-reinforced non-covalent cooperative networks

IF 21.8 2区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES

Advanced Composites and Hybrid Materials Pub Date : 2025-10-01 DOI:10.1007/s42114-025-01453-4

Zhiping Chen, Zhen Xie, Qin Lu, Lingli Tian, Yu Meng, Yichun Xue, Hongxiang Zhu, Lei Wang, Hui He

{"title":"Robust self-pumping medical microneedle arrays by nanofiber-reinforced non-covalent cooperative networks","authors":"Zhiping Chen, Zhen Xie, Qin Lu, Lingli Tian, Yu Meng, Yichun Xue, Hongxiang Zhu, Lei Wang, Hui He","doi":"10.1007/s42114-025-01453-4","DOIUrl":null,"url":null,"abstract":"<div><p>The directional management of exudate drainage and drug delivery assumes paramount importance in the realm of precision therapy for diabetic wounds. Drawing inspiration from the water-collecting and transporting abilities of cactus spines and the water-drinking behavior of spiny lizards, this work designed a robust self-pumping medical microneedle array composed of cellulose nanofibril-reinforced microneedles by non-covalent cooperative bond networks and a Janus backing layer with bidirectional fluid transport capability. Microneedles reinforced with nanofiber exhibit exceptional photothermal conversion efficiency while maintaining sufficient mechanical strength and toughness for epidermal penetration without deformation. The bidirectional Janus backing encompasses a drug delivery zone and a UV-reversibly induced exudate pumping/wettability maintenance zone, enabling staggered transport of the drug and exudates to guarantee long-term efficacy in sustained drug release, controlled exudate removal and microenvironment wettability maintenance. Crucially, it effectively combines broad-spectrum antibacterial, biofilm elimination, antioxidant, biocompatibility and anti-inflammatory functions with edema reduction in diabetic wounds, significantly accelerating the healing process. These findings present an innovative strategy for designing precision therapeutic materials with multimodal wound management capabilities.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 5","pages":""},"PeriodicalIF":21.8000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01453-4.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Composites and Hybrid Materials","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s42114-025-01453-4","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, COMPOSITES","Score":null,"Total":0}

引用次数: 0

Abstract

The directional management of exudate drainage and drug delivery assumes paramount importance in the realm of precision therapy for diabetic wounds. Drawing inspiration from the water-collecting and transporting abilities of cactus spines and the water-drinking behavior of spiny lizards, this work designed a robust self-pumping medical microneedle array composed of cellulose nanofibril-reinforced microneedles by non-covalent cooperative bond networks and a Janus backing layer with bidirectional fluid transport capability. Microneedles reinforced with nanofiber exhibit exceptional photothermal conversion efficiency while maintaining sufficient mechanical strength and toughness for epidermal penetration without deformation. The bidirectional Janus backing encompasses a drug delivery zone and a UV-reversibly induced exudate pumping/wettability maintenance zone, enabling staggered transport of the drug and exudates to guarantee long-term efficacy in sustained drug release, controlled exudate removal and microenvironment wettability maintenance. Crucially, it effectively combines broad-spectrum antibacterial, biofilm elimination, antioxidant, biocompatibility and anti-inflammatory functions with edema reduction in diabetic wounds, significantly accelerating the healing process. These findings present an innovative strategy for designing precision therapeutic materials with multimodal wound management capabilities.

查看原文本刊更多论文

基于纳米纤维增强非共价协同网络的鲁棒自泵医用微针阵列

在糖尿病伤口的精准治疗中，渗出液引流和给药的定向管理是至关重要的。本研究从仙人掌刺的水收集和运输能力以及刺蜥蜴的饮水行为中获得灵感，设计了一种坚固的自泵医用微针阵列，该阵列由非共价协同键网络的纤维素纳米纤维增强微针和具有双向流体输送能力的Janus背层组成。纳米纤维增强的微针具有优异的光热转换效率，同时保持足够的机械强度和韧性，可以在不变形的情况下穿透表皮。双向Janus支持包括药物递送区和紫外线可逆诱导的渗出液泵送/润湿性维持区，使药物和渗出液交错运输，以确保药物持续释放，控制渗出液去除和微环境润湿性维持的长期疗效。至关重要的是，它有效地结合了广谱抗菌、生物膜消除、抗氧化、生物相容性和抗炎功能，减少了糖尿病伤口的水肿，显著加快了愈合过程。这些发现为设计具有多模式伤口管理能力的精密治疗材料提供了一种创新策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Advanced Composites and Hybrid Materials Multiple-

CiteScore

26.00

自引率

21.40%

发文量

185

期刊介绍： Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field. The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest. Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials. Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.