One-Pot Multicomponent Synthesis of Chromene Analogues by HQS@CoFe2O4 Nanocatalyst

IF 2.3 4区化学 Q3 CHEMISTRY, PHYSICAL

Catalysis Letters Pub Date : 2025-10-03 DOI:10.1007/s10562-025-05184-5

K. S. Patil, S. T. Mane, D. M. Sirsat, D. G. Kanase

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Abstract

A green and efficient method has been developed for the synthesis of chromene analogues via atom-economical heterocyclization. This methodology enables ultrarapid and sustainable synthesis of heterocyclic analogues, without generating byproducts and multiple reuse cycles of the nanocatalyst. This process involves the reaction of different aldehydes, 4-hydroxycoumarin, and malononitrile in water using 8-hydroxyquinoline-5-sulfonic acid@CoFe₂O₄ (HQS@CoFe₂O₄) as a magnetic catalyst under mild reaction conditions (70 °C). The procedure offers several advantages, including operational simplicity, high yields (97%), short reaction times, and no need for laborious purification steps. The catalyst demonstrates excellent activity in aqueous media and its easy preparation and straightforward magnetic separation make it a practical and effective heterogeneous system. Notably, the catalyst can be reused multiple times with minimal loss of performance. The synthesized chromene analogues were characterized by melting point, IR, and ¹H NMR spectroscopy, confirming their successful formation.

Graphical Abstract

Abstract Image

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HQS@CoFe2O4纳米催化剂一锅多组分合成铬类似物

开发了一种绿色高效的原子经济性杂环化法制备铬类似物的方法。这种方法可以实现超快速和可持续的杂环类似物合成，而不会产生副产物和纳米催化剂的多次重复使用循环。该过程涉及不同醛、4-羟基香豆素和丙二腈在水中的反应，使用8-羟基喹啉-5-磺酸acid@CoFe2O4 （HQS@CoFe2O4）作为磁性催化剂，在温和的反应条件下（70°C）。该方法具有几个优点，包括操作简单，收率高（97%），反应时间短，不需要费力的纯化步骤。该催化剂在水介质中表现出良好的活性，制备简单、磁分离简单，是一种实用有效的多相体系。值得注意的是，催化剂可以多次重复使用，而性能损失最小。通过熔点、红外光谱和¹H NMR对合成的铬烯类似物进行了表征，证实了它们的成功形成。图形抽象

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来源期刊

Catalysis Letters 化学-物理化学

CiteScore

5.70

自引率

3.60%

发文量

327

审稿时长

1 months

期刊介绍： Catalysis Letters aim is the rapid publication of outstanding and high-impact original research articles in catalysis. The scope of the journal covers a broad range of topics in all fields of both applied and theoretical catalysis, including heterogeneous, homogeneous and biocatalysis. The high-quality original research articles published in Catalysis Letters are subject to rigorous peer review. Accepted papers are published online first and subsequently in print issues. All contributions must include a graphical abstract. Manuscripts should be written in English and the responsibility lies with the authors to ensure that they are grammatically and linguistically correct. Authors for whom English is not the working language are encouraged to consider using a professional language-editing service before submitting their manuscripts.