Multi-Parametric Optical Coherence Tomography Angiography Quantifies Heterogeneous Therapeutic Responses in Port Wine Stains

IF 5.1 2区工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Journal of Selected Topics in Quantum Electronics Pub Date : 2025-09-12 DOI:10.1109/JSTQE.2025.3609623

Xiwan Zhang;Defu Chen;Jinbin Li;Xiaoyu Yang;Yidi Liu;Haixia Qiu;Ying Gu

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引用次数: 0

Abstract

Port wine stains (PWS), congenital vascular malformation, affecting 3 ‰–5 ‰ of newborns, pose significant psychological and social challenges. Current treatments, including vascular-targeted photodynamic therapy (V-PDT), exhibit variable efficacy due to interpatient heterogeneity in vascular characteristics. Here, we present a multi-parametric quantitative method using optical coherence tomography angiography (OCTA) to characterize PWS lesions, analyzing 26 vascular indicators in 100 patients. Our method effectively discriminates patients with distinct therapeutic responses and identifies morphological vascular changes linked to treatment outcomes. By integrating quantitative vascular data with clinical parameters via machine learning, we developed a predictive model that distinguished no-response (NR) from moderate-improvement (MI) and high-improvement (HI) groups with accuracies of 75% and 91%, respectively. This study highlights the importance of understanding vascular pathology to advance personalized treatment strategies for PWS, offering a novel framework for non-invasive evaluation and management of vascular lesions.

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多参数光学相干断层扫描血管造影量化葡萄酒染色的异质治疗反应

波特酒斑（PWS），先天性血管畸形，影响3‰-5‰的新生儿，对心理和社会造成重大挑战。目前的治疗方法，包括血管靶向光动力疗法（V-PDT），由于患者血管特征的异质性，其疗效不一。在这里，我们提出了一种多参数定量方法，使用光学相干断层扫描血管造影（OCTA）来表征PWS病变，分析了100例患者的26项血管指标。我们的方法有效地区分不同治疗反应的患者，并识别与治疗结果相关的形态血管变化。通过机器学习将定量血管数据与临床参数相结合，我们开发了一种预测模型，将无反应（NR）与中度改善（MI）和高度改善（HI）组区分开来，准确率分别为75%和91%。本研究强调了了解血管病理学对推进PWS个性化治疗策略的重要性，为血管病变的无创评估和管理提供了一个新的框架。

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来源期刊

IEEE Journal of Selected Topics in Quantum Electronics 工程技术-工程：电子与电气

CiteScore

10.60

自引率

2.00%

发文量

212

审稿时长

3 months

期刊介绍： Papers published in the IEEE Journal of Selected Topics in Quantum Electronics fall within the broad field of science and technology of quantum electronics of a device, subsystem, or system-oriented nature. Each issue is devoted to a specific topic within this broad spectrum. Announcements of the topical areas planned for future issues, along with deadlines for receipt of manuscripts, are published in this Journal and in the IEEE Journal of Quantum Electronics. Generally, the scope of manuscripts appropriate to this Journal is the same as that for the IEEE Journal of Quantum Electronics. Manuscripts are published that report original theoretical and/or experimental research results that advance the scientific and technological base of quantum electronics devices, systems, or applications. The Journal is dedicated toward publishing research results that advance the state of the art or add to the understanding of the generation, amplification, modulation, detection, waveguiding, or propagation characteristics of coherent electromagnetic radiation having sub-millimeter and shorter wavelengths. In order to be suitable for publication in this Journal, the content of manuscripts concerned with subject-related research must have a potential impact on advancing the technological base of quantum electronic devices, systems, and/or applications. Potential authors of subject-related research have the responsibility of pointing out this potential impact. System-oriented manuscripts must be concerned with systems that perform a function previously unavailable or that outperform previously established systems that did not use quantum electronic components or concepts. Tutorial and review papers are by invitation only.