Sinus Floor Elevation With Platelet-Rich Fibrin From Horizontal Centrifugation and Xenograft: Randomized Clinical Trial

IF 4 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Gabriel Guerra David Reis, Ricardo Júnior Denardi, Sergio Luís Scombatti de Souza, Pedro Henrique Felix Silva, Flávia Furlaneto, Richard J. Miron, Carlos Fernando Mourão, Michel Reis Messora
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引用次数: 0

Abstract

Objective

To evaluate the effects of maxillary sinus augmentation (MSA) using deproteinized bovine bone material (DBBM) combined with or without platelet-rich fibrin obtained by horizontal centrifugation (H-PRF) after a short healing period of 4 months.

Materials and Methods

Thirteen patients underwent bilateral two-stage MSA using a split-mouth model. Each side was randomly assigned to receive DBBM alone (control group) or DBBM + H-PRF (test group). Bone tissue samples were harvested 4 months after implant placement and evaluated using microcomputed tomography (micro-CT), as well as histological and histomorphometric analyses. Data were statistically analyzed using paired t-tests (Wilcoxon signed-rank test; p < 0.05).

Results

Histomorphometric analysis demonstrated higher amounts (p < 0.05) of newly formed bone in the DBBM + H-PRF group compared to the control group (51.33% ± 6.17% versus 45.68% ± 6.65%, respectively). Micro-CT also revealed significantly higher bone volume (30.38% ± 11.24% and 21.38% ± 9.83%, respectively) and connectivity density (4485 ± 1469 and 2562 ± 1271, respectively) in the DBBM + H-PRF group than in the DBBM-alone group (p < 0.05).

Conclusions

Compared with DBBM alone, maxillary sinuses augmented with H-PRF combined with DBBM exhibited improved qualitative and quantitative new bone formation after 4 months of healing. However, the effects on the long-term survival and early stability of dental implants remain unknown and warrant further investigation with long-term follow-up.

Abstract Image

从水平离心和异种移植中获得富血小板纤维蛋白的窦底抬高:随机临床试验。
目的:评价牛去蛋白骨材料(DBBM)联合或不联合水平离心获得的富血小板纤维蛋白(H-PRF)进行上颌窦增强术(MSA)短愈合期4个月后的效果。材料和方法:13例患者采用裂口模型行双侧两期MSA。每组随机分为DBBM单独治疗组(对照组)和DBBM + H-PRF治疗组(试验组)。种植体放置4个月后采集骨组织样本,并使用显微计算机断层扫描(micro-CT)以及组织学和组织形态学分析进行评估。采用配对t检验对数据进行统计学分析(Wilcoxon sign -rank检验;p)结果:组织形态计量学分析显示更高的量(p)结论:与单独DBBM相比,H-PRF联合DBBM增强上颌窦在愈合4个月后,定性和定量的新骨形成都有所改善。然而,对种植体的长期生存和早期稳定性的影响尚不清楚,需要进一步的长期随访研究。
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来源期刊
CiteScore
6.00
自引率
13.90%
发文量
103
审稿时长
4-8 weeks
期刊介绍: The goal of Clinical Implant Dentistry and Related Research is to advance the scientific and technical aspects relating to dental implants and related scientific subjects. Dissemination of new and evolving information related to dental implants and the related science is the primary goal of our journal. The range of topics covered by the journals will include but be not limited to: New scientific developments relating to bone Implant surfaces and their relationship to the surrounding tissues Computer aided implant designs Computer aided prosthetic designs Immediate implant loading Immediate implant placement Materials relating to bone induction and conduction New surgical methods relating to implant placement New materials and methods relating to implant restorations Methods for determining implant stability A primary focus of the journal is publication of evidenced based articles evaluating to new dental implants, techniques and multicenter studies evaluating these treatments. In addition basic science research relating to wound healing and osseointegration will be an important focus for the journal.
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