The discovery, probiotic properties, and genome analysis of Lactiplantibacillus plantarum HP-B1280 with potential therapeutic application for the treatment of non-alcoholic fatty liver disease

IF 1.8 3区生物学 Q4 MICROBIOLOGY

Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology Pub Date : 2025-10-02 DOI:10.1007/s10482-025-02179-5

Wei-Chen Liu, Meng-Jie Liu, Jin-Xiu Jiang, Bing-Yu Ma, Zheng-Jun Ma, Shao-Yang Hou, Hang Wu

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引用次数: 0

Abstract

The anti-inflammatory, antioxidant properties of many probiotic microbes and their ability to modulate the composition of intestinal flora suggest that they have the potential to prevent and/or treat nonalcoholic fatty liver disease (NAFLD). The present study provides evidence that Lactiplantibacillus plantarum HP-B1280 can significantly reduce fat accumulation and inflammatory cell infiltration within the hepatocytes of fatty liver mice and thus may have potential application value in the prophylaxis and treatment of NAFLD disease. HP-B1280 also exhibits an extremely high level of resistance to acids and bile salts. The fermentation broth of HP-B1280 cultures is effectively suppresses the growth of a variety of common human pathogens. A comprehensive analysis of the complete genome sequence of L. plantarum HP-B1280 was conducted. Results indicated that the genome of L. plantarum HP-B1280 was devoid of resistance genes, drug resistance genes, as well as virulence factors. The annotation of the genome provides a foundation for further studies on the mechanism underlying the prevention and treatment of NAFLD by L. plantarum HP-B1280. In summary, the findings of the present study provides valuable insights into the potential use of probiotics, such as L. plantarum HP-B1280 in the amelioration and prophylaxis of NAFLD.

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植物乳杆菌HP-B1280的发现、益生菌特性和基因组分析及其在非酒精性脂肪肝治疗中的潜在应用

许多益生菌微生物的抗炎、抗氧化特性及其调节肠道菌群组成的能力表明，它们具有预防和/或治疗非酒精性脂肪性肝病（NAFLD）的潜力。本研究证明植物乳杆菌HP-B1280能显著减少脂肪肝小鼠肝细胞内脂肪堆积和炎症细胞浸润，在NAFLD疾病的预防和治疗中具有潜在的应用价值。HP-B1280对酸和胆盐也有极高的抵抗力。HP-B1280培养物的发酵液能有效抑制多种常见人类病原体的生长。对植物L. plantarum HP-B1280的全基因组序列进行了综合分析。结果表明，植物L. plantarum HP-B1280基因组缺乏耐药基因、耐药基因和毒力因子。该基因组的注释为进一步研究植物l.s plantarum HP-B1280防治NAFLD的机制奠定了基础。总之，本研究的发现为益生菌如植物乳杆菌HP-B1280在改善和预防NAFLD中的潜在应用提供了有价值的见解。

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来源期刊

Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology 生物-微生物学

CiteScore

5.60

自引率

11.50%

发文量

104

审稿时长

3 months

期刊介绍： Antonie van Leeuwenhoek publishes papers on fundamental and applied aspects of microbiology. Topics of particular interest include: taxonomy, structure & development; biochemistry & molecular biology; physiology & metabolic studies; genetics; ecological studies; especially molecular ecology; marine microbiology; medical microbiology; molecular biological aspects of microbial pathogenesis and bioinformatics.