ZNRF3 in neurodevelopmental disorders: insights into Wnt signaling and therapeutic potential.

IF 1.2 4区医学 Q3 CLINICAL NEUROLOGY

Neurogenetics Pub Date : 2025-10-02 DOI:10.1007/s10048-025-00852-5

Yasmin Yusuf Hussein Dinle, Ruping Liu, Mainak Sengupta, Rakesh Kumar Panjaliya, Parimal Das, Anjana Munshi, Samraggi Chakraborty, Jinghua Li, Baiyu Qi, Zakaria Ahmed Mohamed, Qian Tong, Mingyou Zhang, Jianping Wen, Santasree Banerjee

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引用次数: 0

Abstract

Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), and intellectual disabilities (ID), have seen an increasing prevalence in recent years. Both genetic and environmental factors have been implicated in the pathogenesis of these conditions. One such gene, ZNRF3, plays a pivotal role in regulating neural cell growth and connectivity, with variations in this gene linked to disruptions in neural differentiation and communication. This review synthesizes genetic, molecular, and clinical research to examine the role of ZNRF3 in brain development. Furthermore, it explores the impact of prenatal environmental exposures and healthcare policies on diagnostic practices and treatment accessibility. The findings highlight the need for improved genetic screening, early intervention strategies, and policy reforms aimed at facilitating personalized care for individuals affected by ZNRF3-related NDDs.

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ZNRF3在神经发育障碍中的作用：对Wnt信号传导和治疗潜力的见解。

神经发育障碍（ndd），包括自闭症谱系障碍（ASD）、注意力缺陷多动障碍（ADHD）和智力障碍（ID），近年来越来越普遍。遗传和环境因素都与这些疾病的发病机制有关。其中一个基因ZNRF3在调节神经细胞生长和连通性方面起着关键作用，该基因的变异与神经分化和通讯的中断有关。本文综述了ZNRF3在脑发育中的遗传、分子和临床研究。此外，它探讨了产前环境暴露和医疗保健政策对诊断实践和治疗可及性的影响。研究结果强调了改进遗传筛查、早期干预策略和政策改革的必要性，旨在促进对受znrf3相关ndd影响的个体的个性化护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurogenetics 医学-临床神经学

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Neurogenetics publishes findings that contribute to a better understanding of the genetic basis of normal and abnormal function of the nervous system. Neurogenetic disorders are the main focus of the journal. Neurogenetics therefore includes findings in humans and other organisms that help understand neurological disease mechanisms and publishes papers from many different fields such as biophysics, cell biology, human genetics, neuroanatomy, neurochemistry, neurology, neuropathology, neurosurgery and psychiatry. All papers submitted to Neurogenetics should be of sufficient immediate importance to justify urgent publication. They should present new scientific results. Data merely confirming previously published findings are not acceptable.