Personality traits associated with tinnitus: A systematic review and contributing genetic variants

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews Pub Date : 2025-09-29 DOI:10.1016/j.neubiorev.2025.106389

Alberto Bernal-Robledano , Alberto M. Parra-Perez , M.del Carmen Moleon , Jose A. Lopez-Escámez , Patricia Perez-Carpena

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引用次数: 0

Abstract

Chronic tinnitus is multifaceted condition associated with auditory (hearing loss, hyperacusis), neurological (headache) and psychological disorders (anxiety, depression). Personality traits may determine how tinnitus is perceived, and common genetic variation contributes to shape personality. The goal of this systematic review is to analyze evidence supporting a link between personality traits and tinnitus. Published articles about tinnitus and personality related to the Big Five Traits were included. Based on 7 studies, this systematic review identified the neuroticism trait as the main potential connection between personality and tinnitus suffering. The consistency of this relationship is evident across different Big Five personality tools, with similar outcomes observed regardless of the instrument used, reinforcing the consistency of this association. In order to establish a genetics association, a GWAS based search revealed common genetic variants in the GRM5, XKR6, GRM8, TCF4, and SLC39A8 genes, with SLC39A8 identified as a shared missense variant rs13107325 (C/T, p.Ala391Thr) between neuroticism and tinnitus. The role of these genes in important neural functions points to possible shared mechanisms underlying both conditions.

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与耳鸣相关的人格特征：系统回顾和贡献基因变异。

慢性耳鸣是一种多方面的疾病，与听觉（听力损失、听觉亢进）、神经（头痛）和心理障碍（焦虑、抑郁）有关。性格特征可能决定耳鸣如何被感知，而常见的遗传变异有助于塑造个性。本系统综述的目的是分析支持人格特征和耳鸣之间联系的证据。已发表的关于耳鸣和与五大特征相关的人格的文章被包括在内。基于7项研究，本系统综述确定了神经质特征是人格与耳鸣痛苦之间的主要潜在联系。这种关系的一致性在不同的五大人格工具中很明显，无论使用哪种工具，观察到的结果都是相似的，这加强了这种关联的一致性。为了建立遗传关联，基于GWAS的搜索发现了GRM5、XKR6、GRM8、TCF4和SLC39A8基因的共同遗传变异，其中SLC39A8被确定为神经质和耳鸣之间的共同变异。这些基因在重要的神经功能中的作用指出了这两种疾病可能存在的共同机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience and Biobehavioral Reviews 医学-行为科学

CiteScore

14.20

自引率

3.70%

发文量

466

审稿时长

6 months

期刊介绍： The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.