Positive Cortisol–Testosterone Hormonal Coupling Among Adolescents in Argentina and Jordan

IF 2 2区 生物学 Q1 ANTHROPOLOGY
Delaney J. Glass, Jessica Godwin, Josefin Koehn, Eleanna Bez, Margaret Corley, Rana Dajani, Kristin Hadfield, Catherine Panter-Brick, Claudia Valeggia, Melanie Martin
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Abstract

Objectives

Puberty is regulated by the hypothalamic–pituitary–adrenal (HPA) and gonadal (HPG) axes. It has been proposed that if HPA and HPG coactivate during pubertal development, the hormones cortisol and testosterone would be positively coupled during puberty and decoupled postpuberty. Our objective was to test for hormonal coupling in less-studied, non-Western populations.

Materials and Methods

We analyzed longitudinal and cross-sectional data from marginalized populations: Indigenous Qom/Toba females in Argentina (n = 46, 777 urine samples) and Syrian/Jordanian youth (n = 768, dried blood spots). We used Bayesian hierarchical models to assess the hypothesis that cortisol and testosterone are positively coupled during puberty but decouple at later stages.

Results

We found positive, age-specific cortisol–testosterone coupling among adolescents in both populations, with patterns varying by age and sex. Coupling increased across pubertal ages but did not decline at older ages, contradicting the expectation that there is hormonal de-coupling.

Discussion

This is the first study to demonstrate positive cortisol–testosterone coupling across adolescence in two socio-ecologically distinct, non-Western populations. While hormonal decoupling was not observed, coupling patterns suggest population-level differences in pubertal timing. These findings challenge assumptions derived from Western-based research and underscore the need for global, context-sensitive models of adolescent development.

Abstract Image

阿根廷和约旦青少年皮质醇-睾酮激素耦合阳性。
目的:青春期是由下丘脑-垂体-肾上腺(HPA)和性腺(HPG)轴调控的。如果HPA和HPG在青春期发育过程中共同激活,那么皮质醇和睾酮在青春期期间是正偶联的,而在青春期后是解耦的。我们的目的是在研究较少的非西方人群中测试激素偶联。材料和方法:我们分析了来自边缘人群的纵向和横断面数据:阿根廷土著库姆/多巴族女性(n = 46, 777份尿液样本)和叙利亚/约旦青年(n = 768,干血斑)。我们使用贝叶斯层次模型来评估皮质醇和睾酮在青春期正耦合但在后期分离的假设。结果:我们在两种人群中都发现了阳性的、年龄特异性的皮质醇-睾酮偶联,其模式因年龄和性别而异。在青春期,偶联性增加,但随着年龄的增长,偶联性并没有下降,这与激素脱钩的预期相矛盾。讨论:这是第一个在两个社会生态学不同的非西方人群中证明青春期皮质醇-睾酮正耦合的研究。虽然没有观察到激素脱钩,但耦合模式表明青春期时间在人口水平上存在差异。这些发现挑战了基于西方研究的假设,并强调了对青少年发展的全球、情境敏感模型的需求。
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CiteScore
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