Listeria monocytogenes: Host-pathogen interactions and innate immune response.

IF 3.4 4区生物学 Q3 MICROBIOLOGY

Research in microbiology Pub Date : 2025-09-29 DOI:10.1016/j.resmic.2025.104342

Shahidul Ahmed Khan, Yeon Soo Han

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引用次数: 0

Abstract

Listeria monocytogenes is primarily a saprophytic bacterium, but it can transition into a pathogenic form when ingested by humans, vertebrates, or invertebrates, thereby initiating infection and proliferating within the host. This bacterium serves as a model for studying the molecular and cellular mechanisms by which environmental microorganisms adapt to mammalian and other host systems, thereby promoting the successful colonization and survival of these microorganisms. Environmental contamination is a significant factor in the transmission of listeriosis and other foodborne diseases. This review provides a comprehensive examination of the microbiological characteristics of L. monocytogenes. It systematically evaluates host-pathogen interactions, focusing on a range of clinically relevant isolates and their pathogenic mechanisms. Furthermore, it evaluates in vitro models employed to investigate the virulence factors of the pathogen while also considering the role of animal models, including Drosophila melanogaster and other insect species, in elucidating infection dynamics. In addition, it discusses the host's innate immune response, specifically highlighting the molecular and cellular pathways activated upon infection, thereby providing a comprehensive understanding of the pathogen's interactions with the host's immune system.

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单核增生李斯特菌：宿主-病原体相互作用和先天免疫反应。

单核增生李斯特菌主要是一种腐生菌，但当被人类、脊椎动物或无脊椎动物摄入后，它可以转变为致病性形式，从而在宿主体内引发感染和增殖。这种细菌可以作为研究环境微生物适应哺乳动物和其他宿主系统的分子和细胞机制的模型，从而促进这些微生物的成功定植和生存。环境污染是李斯特菌病和其他食源性疾病传播的一个重要因素。本文综述了单核增生乳杆菌的微生物学特性。它系统地评估宿主-病原体相互作用，重点关注一系列临床相关的分离株及其致病机制。此外，它评估了用于研究病原体毒力因素的体外模型，同时也考虑了动物模型的作用，包括黑腹果蝇和其他昆虫物种，在阐明感染动力学方面。此外，它还讨论了宿主的先天免疫反应，特别强调了感染时激活的分子和细胞途径，从而提供了对病原体与宿主免疫系统相互作用的全面了解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in microbiology 生物-微生物学

CiteScore

4.10

自引率

3.80%

发文量

审稿时长

16 days

期刊介绍： Research in Microbiology is the direct descendant of the original Pasteur periodical entitled Annales de l''Institut Pasteur, created in 1887 by Emile Duclaux under the patronage of Louis Pasteur. The Editorial Committee included Chamberland, Grancher, Nocard, Roux and Straus, and the first issue began with Louis Pasteur''s "Lettre sur la Rage" which clearly defines the spirit of the journal:"You have informed me, my dear Duclaux, that you intend to start a monthly collection of articles entitled "Annales de l''Institut Pasteur". You will be rendering a service that will be appreciated by the ever increasing number of young scientists who are attracted to microbiological studies. In your Annales, our laboratory research will of course occupy a central position, but the work from outside groups that you intend to publish will be a source of competitive stimulation for all of us."That first volume included 53 articles as well as critical reviews and book reviews. From that time on, the Annales appeared regularly every month, without interruption, even during the two world wars. Although the journal has undergone many changes over the past 100 years (in the title, the format, the language) reflecting the evolution in scientific publishing, it has consistently maintained the Pasteur tradition by publishing original reports on all aspects of microbiology.