Functional Outcome After Initial and Multiple Intracerebral Hemorrhage in Patients With a Brainstem Cavernous Malformation: An International Multicenter Collaboration.

Abstract

Background and objectives: Brainstem cavernous malformations (BSCM) can result in spontaneous intracerebral hemorrhage (ICH), often resulting in significant morbidity. We aimed to assess the functional outcome and identify predictors of functional neurological outcome after single and multiple symptomatic hemorrhages.

Methods: As part of an international multicenter collaboration, institutional databases from 3 different tertiary referral centers included BSCM patients with complete baseline characteristics, MRI Data set, ≥1 ICH, and ≥1 follow-up examination followed at our institutions between 2003 and 2023. Functional neurological outcome was obtained using the modified Rankin Scale at diagnosis, before and after each ICH, and last follow-up. Patients were excluded after surgical removal of the lesion and/or loss of follow-up.

Results: A total of 383 patients (41.47 ± 15.51 age; 220 [57.4%] female) were included and followed for an average of 63.16 ± 85.75 months. Functional neurological outcome deteriorated in 47.2% (P = .010) after the second ICH and in 46.5% (P = .007) after the third ICH. Moreover, the functional neurological status was impaired in 22.3% (P < .001) of patients at last available follow-up compared with the time of BSCM diagnosis.

Conclusion: In our study, we observed that the chance of full recovery might decrease with each ICH. We observed a significantly associated neurological deterioration after each ICH compared with initial ICH.