Treatment With Remdesivir Alone or in Combination With GS-441524 in Cats With Ocular Involvement of Feline Infectious Peritonitis: An Observational Case Series

IF 2.2 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine Pub Date : 2025-10-01 DOI:10.1111/jvim.70253

Amy L. M. M. Andrews, Eneko Izaguirre, Jodie Green, Emma Scurrell, Savina Gogova, Sarah Tayler, Christiane Kafarnik

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引用次数: 0

Abstract

Background

Remdesivir and GS-441524 have successfully treated cats with feline infectious peritonitis (FIP) but the changes in associated signs of ocular disease are not reported.

Objective

Evaluate the response of FIP-associated signs of ocular disease before and after treatment with remdesivir, GS-441524, or both.

Animals

Sixty-one cats diagnosed with FIP by the Internal Medicine services between October 2021 and December 2022 that were treated with injectable, oral, or a combination of anti-viral therapies were reviewed.

Methods

Observation study. Signalment, associated signs of ocular disease, treatment, outcome, and follow-up of affected cats were analyzed.

Results

Associated signs of ocular disease in cats with FIP were diagnosed in 33% (20/61) cats, with a median follow-up of 55 days (IQR 47.3–90.8, range: 16–1071 days) in 11 cats with FIP. Ocular changes were all associated with uveitis, of which 20% (4/20) had anterior uveitis, 25% (5/20) had posterior uveitis, and 55% (11/20) had panuveitis. Ocular disease occurred in effusive (11/20; 55%) and non-effusive (9/20; 45%) FIP and was bilateral in 70% (14/20) cats. All cats started an 84-day course of treatment, with the majority (17/20; 85%) receiving remdesivir in the initial period. Of those, 70% (12/17) received a high dose of 15–20 mg/kg/day. Eleven cats with uveitis had long-term follow-up nine (9/11; 82%) of these had resolution of uveitis. Eighty-seven percent (13/15) of cases with anterior uveitis received topical anti-inflammatory medication. Eighty percent (16/20) of cats survived.

Conclusion and Clinical Importance

Cats with FIP commonly have ocular involvement. Associated uveitis responded to remdesivir or GS-441524 treatment effectively in 82% of cases.

Abstract Image

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瑞德西韦单独或联合GS-441524治疗猫感染性腹膜炎累及眼部：观察性病例系列

背景：Remdesivir和GS-441524已成功治疗猫传染性腹膜炎（FIP），但眼部疾病相关体征的变化未见报道。目的：评估瑞德西韦、GS-441524或两者治疗前后眼部疾病fip相关体征的反应。动物：在2021年10月至2022年12月期间，对61只被内科服务部门诊断患有FIP的猫进行了回顾，这些猫接受了注射、口服或抗病毒治疗的组合治疗。方法：观察研究。对受影响猫的眼病信号、相关症状、治疗、结果和随访进行分析。结果：33%（20/61）的FIP猫被诊断出眼部疾病的相关症状，11只FIP猫的中位随访时间为55天（IQR 47.3-90.8，范围：16-1071天）。眼部变化均与葡萄膜炎相关，其中20%（4/20）为前葡萄膜炎，25%（5/20）为后葡萄膜炎，55%（11/20）为全葡萄膜炎。眼部疾病发生在渗出性FIP（11/20; 55%）和非渗出性FIP（9/20; 45%）中，70%（14/20）猫为双侧。所有猫开始84天的疗程，大多数猫（17/20;85%）在初始阶段接受瑞德西韦治疗。其中，70%（12/17）接受了15- 20mg /kg/天的高剂量治疗。11只患有葡萄膜炎的猫进行了长期随访，其中9只（9/11;82%）葡萄膜炎消退。87%（13/15）的前葡萄膜炎患者接受了局部抗炎药物治疗。80%（16/20）的猫存活了下来。结论及临床意义：FIP猫通常有眼部受累。82%的病例对瑞德西韦或GS-441524治疗有效。

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来源期刊

Journal of Veterinary Internal Medicine 农林科学-兽医学

CiteScore

4.50

自引率

11.50%

发文量

243

审稿时长

22 weeks

期刊介绍： The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.