Triple-Negative Breast Cancer, Recurrence, and Survival Outcomes in Young Black Women.

IF 2.4 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Racial and Ethnic Health Disparities Pub Date : 2025-10-02 DOI:10.1007/s40615-025-02630-3

Regina Matar-Ujvary, Sara P Myers, Simran Malhotra, Varadan Sevilimedu, Mary L Gemignani

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Abstract

Background: Triple-negative breast cancer (TNBC) accounts for 40-50% of breast cancers in young Black women. Black women have an increased risk of death due to TNBC than White women; whether age contributes to worse outcomes in the setting of a high-risk tumor subtype is unclear.

Methods: Our retrospective review of an institutional database identified Black women with operable TNBC from 2005 to 2020. Clinicopathologic, treatment, and outcome variables in women aged < 40 (young adults [YAs] cohort) were compared to those ≥ 40 years using Cox proportional hazard models. Kaplan-Meier method estimated overall survival (OS) and breast cancer-specific survival (BCSS).

Results: We identified 397 Black women with a median age of 55 (range 23-88); 39 (9.8%) were < 40 and 358 (90.2%) were ≥ 40. The YA cohort were more likely to have a BRCA mutation and present with a physical finding and more advanced clinical stage (all p < 0.01). Compared with women ≥ 40 years, those < 40 were more likely to receive mastectomy (61.5% vs. 31.3%; p < 0.001) and neoadjuvant chemotherapy (46.2% vs. 26.7%; p = 0.05), and not receive adjuvant radiotherapy (35.9% vs. 18.8%; p = 0.008). At a median follow-up of 6.2 years, the 5-year OS and BCSS rates were 81.2% and 84.0% in women < 40 years old, and 80.9% and 85.3% in those ≥ 40 (p = 0.45 and p = 0.75, respectively).

Conclusion: Young age at diagnosis in Black women with TNBC was not an independent predictor of locoregional recurrence, distant recurrence, OS, or BCSS despite being associated with higher stage of disease.

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年轻黑人女性的三阴性乳腺癌、复发和生存结局。

背景：三阴性乳腺癌（TNBC）占年轻黑人女性乳腺癌的40-50%。黑人妇女因TNBC死亡的风险高于白人妇女；在高风险肿瘤亚型的情况下，年龄是否会导致更差的预后尚不清楚。方法：我们回顾性回顾了一个机构数据库，从2005年到2020年确定了可手术的TNBC黑人妇女。老年女性的临床病理、治疗和结局变量结果：我们确定了397名黑人女性，中位年龄为55岁（范围23-88岁）；结论：黑人女性TNBC的年轻诊断年龄并不是局部复发、远处复发、OS或BCSS的独立预测因子，尽管它与较高的疾病分期相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Racial and Ethnic Health Disparities PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

7.30

自引率

5.10%

发文量

263

期刊介绍： Journal of Racial and Ethnic Health Disparities reports on the scholarly progress of work to understand, address, and ultimately eliminate health disparities based on race and ethnicity. Efforts to explore underlying causes of health disparities and to describe interventions that have been undertaken to address racial and ethnic health disparities are featured. Promising studies that are ongoing or studies that have longer term data are welcome, as are studies that serve as lessons for best practices in eliminating health disparities. Original research, systematic reviews, and commentaries presenting the state-of-the-art thinking on problems centered on health disparities will be considered for publication. We particularly encourage review articles that generate innovative and testable ideas, and constructive discussions and/or critiques of health disparities.Because the Journal of Racial and Ethnic Health Disparities receives a large number of submissions, about 30% of submissions to the Journal are sent out for full peer review.