Multicontrast Multiphase Intestinal Imaging Using Photon-Counting CT: A Feasibility Study in Rats.

IF 8 1区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Investigative Radiology Pub Date : 2025-10-02 DOI:10.1097/RLI.0000000000001241

Jonas Neumann, Gregor Jost, Ralf Gutjahr, Tristan Nowak, Jessica Lohrke, Bernhard Schmidt, Joachim von Zanthier, Hubertus Pietsch

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引用次数: 0

Abstract

Objectives: The aim of this study is to validate a 3-material decomposition algorithm for distinguishing between 2 contrast media (CM) (iodine-based and tungsten-based) and water in vivo using a commercial photon-counting CT (PCCT) unit, able to acquire 4 energy thresholds simultaneously.

Materials and methods: Six healthy rats were imaged during different CM distribution phases with both iodine-based and tungsten-based CM present in the animals, one administered orally and one intravenously. Material decomposition was used to compute quantitative contrast maps, virtual noncontrast (VNC) maps, and virtual monoenergetic images (VMI). The mean enhancement in CM-filled regions and in CM-free muscle was measured. This prospective preclinical study was conducted in accordance with the German Animal Welfare Act guidelines and with the approval of the local state animal welfare committee.

Results: Iodine-filled regions were exclusively enhanced (P<0.001) in the iodine map. Tungsten-filled regions were exclusively enhanced (P<0.001) in the tungsten map. VNC maps of a 3-material decomposition received no additional enhancement by CM. VMI, incorporating both iodine and tungsten CM, of different energy levels indicated the K-edge of tungsten.

Conclusions: This study successfully demonstrated the capability of PCCT combined with material decomposition to delineate 2 CM and water in rats. The contrast dynamics of the 2 CM in the vessels (aorta and vena cava) and intestines were successfully reproduced in the CM maps. VNC maps may omit the need for CT scans before contrast administration. VMI revealed distinct energy-dependent attenuation profiles of the given materials.

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光子计数CT在大鼠肠道多对比多相成像的可行性研究。

目的：本研究的目的是利用商用光子计数CT （PCCT）装置验证一种3-材料分解算法，该算法可以在体内区分两种造影剂（碘基和钨基）和水，该装置能够同时获得4个能量阈值。材料和方法：6只健康大鼠在不同CM分布阶段成像，其中碘基CM和钨基CM同时存在，一个口服，一个静脉注射。材料分解用于计算定量对比图、虚拟非对比图（VNC）和虚拟单能图像（VMI）。测量cm填充区和无cm肌肉的平均增强。这项前瞻性临床前研究是按照德国动物福利法的指导方针进行的，并得到了当地国家动物福利委员会的批准。结果：碘填充区独占增强(p)结论：本研究成功证明了PCCT结合物质分解对大鼠2cm和水的描绘能力。血管（主动脉和腔静脉）和肠道内2cm的对比动态在CM图中成功再现。VNC映射可以在给药前省去CT扫描的需要。VMI显示了给定材料明显的能量依赖衰减曲线。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Investigative Radiology 医学-核医学

CiteScore

15.10

自引率

16.40%

发文量

188

审稿时长

4-8 weeks

期刊介绍： Investigative Radiology publishes original, peer-reviewed reports on clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, and related modalities. Emphasis is on early and timely publication. Primarily research-oriented, the journal also includes a wide variety of features of interest to clinical radiologists.