The intersection of ferroptosis and non-coding RNAs: a novel approach to lung cancer.

IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Jian Ding
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Abstract

Lung cancer remains a major global health challenge, with non-small cell lung cancer (NSCLC) accounting for nearly 85% of cases and deaths. Although advances in targeted therapy and immunotherapy have improved patient outcomes, drug resistance and limited long-term survival continue to pose serious obstacles. Ferroptosis, an iron-dependent and lipid peroxidation-driven form of regulated cell death, has attracted growing attention as a novel therapeutic approach to address these challenges. At the same time, non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs, and circular RNAs, are increasingly recognized as crucial regulators of cancer progression, therapy resistance, and cellular homeostasis. Recent studies reveal that ncRNAs and ferroptosis are closely interconnected in lung cancer, with ncRNAs influencing iron metabolism, antioxidant defense, and lipid peroxidation, thereby modulating sensitivity or resistance to ferroptotic death. Importantly, this crosstalk not only shapes tumor biology but also provides opportunities for clinical translation. Ferroptosis-related ncRNAs are emerging as potential biomarkers for prognosis, therapeutic response, and disease stratification. In addition, pharmacological induction of ferroptosis, combined with modulation of specific ncRNAs, offers a promising strategy to overcome resistance to chemotherapy, radiotherapy, and immunotherapy. This review highlights the latest advances in understanding the interplay between ncRNAs and ferroptosis in lung cancer and discusses their implications for precision medicine. By integrating ferroptosis induction with ncRNA-targeted strategies, new avenues may emerge for developing more effective and personalized therapies against NSCLC.

铁下垂与非编码rna的交叉:一种治疗肺癌的新方法。
肺癌仍然是一个主要的全球健康挑战,非小细胞肺癌(NSCLC)占病例和死亡人数的近85%。尽管靶向治疗和免疫治疗的进展改善了患者的预后,但耐药性和有限的长期生存仍然构成严重障碍。铁下垂是一种铁依赖性和脂质过氧化驱动的调节细胞死亡形式,作为一种新的治疗方法来解决这些挑战,已经引起了越来越多的关注。与此同时,非编码rna (ncRNAs),包括microRNAs、长链非编码rna和环状rna,越来越多地被认为是癌症进展、治疗耐药性和细胞稳态的关键调节因子。最近的研究表明,ncRNAs与肺癌中的铁凋亡密切相关,ncRNAs影响铁代谢、抗氧化防御和脂质过氧化,从而调节对铁凋亡的敏感性或抗性。重要的是,这种串扰不仅塑造了肿瘤生物学,而且为临床翻译提供了机会。与铁凋亡相关的ncrna正在成为预后、治疗反应和疾病分层的潜在生物标志物。此外,药物诱导铁下垂,结合特异性ncrna的调节,为克服化疗、放疗和免疫治疗的耐药提供了一种有希望的策略。本文综述了ncrna与肺癌铁下垂之间相互作用的最新进展,并讨论了它们对精准医学的影响。通过将铁下垂诱导与ncrna靶向策略结合,可能会出现开发更有效和个性化的非小细胞肺癌治疗方法的新途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Irish Journal of Medical Science
Irish Journal of Medical Science 医学-医学:内科
CiteScore
3.70
自引率
4.80%
发文量
357
审稿时长
4-8 weeks
期刊介绍: The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.
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