Exercise-mediated cerebrovascular repair in Alzheimer's disease: from pathophysiology to therapeutic precision.

IF 4.5 2区医学 Q2 GERIATRICS & GERONTOLOGY

Frontiers in Aging Neuroscience Pub Date : 2025-09-16 eCollection Date: 2025-01-01 DOI:10.3389/fnagi.2025.1632365

Ming Cai, Keren Cai, Ziqi Wei, Jing Zhou, Jiayi Shu, Weiyi Wang, Wanju Sun, Jingyun Hu

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Abstract

Cerebrovascular dysfunctions, encompassing changes in cerebrovascular microstructure, blood-brain barrier (BBB) integrity, cerebrovascular reactivity, and cerebral blood flow (CBF), accelerate the pathological progression of Alzheimer's disease (AD). Exercise emerges as a promising non-pharmacological intervention that enhances cerebrovascular repair for the treatment of AD. This review summarizes the pathological vascular changes in AD pathology, such as pericyte loss, endothelial dysfunction, and capillary fibrosis, which exacerbate hypoperfusion, hypoxia, and amyloidogenesis. We further discuss the contributing vascular factors and underlying signaling mechanisms to explore potential targets for AD diagnosis and therapy. Finally, we present evidence concerning the impact of exercise on cerebral vascular signaling and the cells involved in vascular plasticity. We also address the impact of various exercise patterns on cerebrovascular health. This work aims to uncover the potential and intervention effects of exercise on cerebrovascular non-malignant alterations and will provide exercise strategies for treating AD.

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阿尔茨海默病运动介导的脑血管修复：从病理生理学到治疗精度。

脑血管功能障碍，包括脑血管微结构、血脑屏障（BBB）完整性、脑血管反应性和脑血流量（CBF）的改变，加速了阿尔茨海默病（AD）的病理进展。运动作为一种有希望的非药物干预手段，可以增强AD治疗的脑血管修复。本文综述了阿尔茨海默病病理中的病理性血管变化，如周细胞丢失、内皮功能障碍和毛细血管纤维化，这些变化加剧了灌注不足、缺氧和淀粉样变的发生。我们进一步讨论了相关的血管因素和潜在的信号机制，以探索AD诊断和治疗的潜在靶点。最后，我们提出了关于运动对脑血管信号和参与血管可塑性的细胞的影响的证据。我们还讨论了各种运动模式对脑血管健康的影响。这项工作旨在揭示运动对脑血管非恶性改变的潜在和干预作用，并为治疗AD提供运动策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.