Advances in diagnostic techniques for eosinophilic esophagitis: a systematic review of emerging noninvasive methods.

IF 3.4 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Abdulrhman Khaled Al Abdulqader
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引用次数: 0

Abstract

Background: Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease characterized by esophageal dysfunction and eosinophilic inflammation. Traditional diagnostic methods rely on endoscopy with biopsy, which is invasive and resource-intensive. The recent advancements have focused on developing noninvasive and minimally invasive diagnostic tools to improve patient experience and facilitate disease monitoring.

Objective: This systematic review aims to evaluate emerging noninvasive diagnostic techniques for EoE, including biomarkers, esophageal string tests (EST), and advanced imaging modalities, and their potential to complement or replace conventional diagnostic methods.

Methods: A systematic search was conducted in major databases, including PubMed, Embase, and Cochrane Library, to identify studies investigating noninvasive diagnostic approaches for EoE. Inclusion criteria focused on original research and clinical trials evaluating diagnostic accuracy, patient acceptability, and clinical utility. Data on diagnostic methods, outcomes, and limitations were extracted and analyzed.

Results: Emerging diagnostic methods, such as blood and urine biomarkers (e.g., EDN, ECP, eotaxin-3), EST, and advanced imaging (e.g., optical coherence tomography, EndoFLIP), demonstrated comparable sensitivity and specificity to endoscopic biopsy in detecting EoE. These tools offer advantages in reducing procedural burden, enabling dynamic disease monitoring, and enhancing patient adherence. However, challenges include variability in diagnostic thresholds and limited large-scale validation.

Conclusion: Noninvasive diagnostic tools for EoE hold promise in transforming clinical practice by reducing reliance on invasive endoscopy. Further research is needed to standardize protocols and validate these methods for routine use.

嗜酸性粒细胞性食管炎诊断技术的进展:对新兴非侵入性方法的系统回顾。
背景:嗜酸性粒细胞性食管炎(EoE)是一种以食管功能障碍和嗜酸性粒细胞性炎症为特征的慢性免疫介导性疾病。传统的诊断方法依赖于内镜活检,这是侵入性的和资源密集的。最近的进展主要集中在开发无创和微创诊断工具,以改善患者体验和促进疾病监测。目的:本系统综述旨在评估新兴的EoE无创诊断技术,包括生物标志物、食管弦试验(EST)和先进的成像方式,以及它们补充或取代传统诊断方法的潜力。方法:系统检索主要数据库,包括PubMed、Embase和Cochrane图书馆,以确定研究EoE无创诊断方法的研究。纳入标准侧重于评估诊断准确性、患者可接受性和临床实用性的原始研究和临床试验。提取和分析诊断方法、结果和局限性的数据。结果:新兴的诊断方法,如血液和尿液生物标志物(如EDN、ECP、eotaxin-3)、EST和先进的成像技术(如光学相干断层扫描、EndoFLIP),在检测EoE方面显示出与内镜活检相当的敏感性和特异性。这些工具在减少程序负担、实现动态疾病监测和提高患者依从性方面具有优势。然而,挑战包括诊断阈值的可变性和有限的大规模验证。结论:通过减少对侵入性内窥镜检查的依赖,无创诊断工具有望改变临床实践。需要进一步的研究来标准化协议并验证这些方法的日常使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
European Journal of Medical Research
European Journal of Medical Research 医学-医学:研究与实验
CiteScore
3.20
自引率
0.00%
发文量
247
审稿时长
>12 weeks
期刊介绍: European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.
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