Poor sleep health is associated with older brain age: the role of systemic inflammation.

IF 10.8 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

EBioMedicine Pub Date : 2025-10-01 Epub Date: 2025-09-30 DOI:10.1016/j.ebiom.2025.105941

Yuyang Miao, Jiao Wang, Xuerui Li, Jie Guo, Maria M Ekblom, Shireen Sindi, Qiang Zhang, Abigail Dove

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引用次数: 0

Abstract

Background: Poor-quality sleep has been linked to increased dementia risk. We investigated the relationship between healthy sleep pattern and older brain age, and the extent to which this is mediated by systemic inflammation.

Methods: The study included 27,500 adults from the UK Biobank (mean age 54.7 y, 54.0% female). The presence of five self-reported healthy sleep characteristics (early chronotype, 7-8 h daily sleep, no insomnia, no snoring, no excessive daytime sleepiness) were summed into a healthy sleep score (0-5 pts) and used to define three sleep patterns: healthy (≥4 pts), intermediate (2-3 pts), and poor (≤1 pt). Low-grade inflammation was estimated using the INFLA-score, a composite index of inflammatory biomarkers. After a mean follow-up of 8.9 y, brain age was estimated using a machine learning model based on 1079 brain MRI phenotypes and used to calculate brain age gap (BAG; i.e., brain age minus chronological age). Data were analysed using linear regression and generalised structural equation models.

Findings: At baseline, 898 (3.3%) participants had poor sleep, 15,283 (55.6%) had intermediate sleep, and 11,319 (41.2%) had healthy sleep. Compared to healthy sleep, intermediate (β = 0.25 [0.11, 0.40], P = 0.010) and poor (β = 0.46 [0.05, 0.87], P < 0.001) sleep were associated with significantly higher BAG. In mediation analysis, INFLA-score mediated 6.81% and 10.42% of the associations between intermediate and poor sleep and higher BAG.

Interpretation: Poor sleep health may accelerate brain ageing. This may be driven by higher levels of systemic inflammation.

Funding: Alzheimerfonden; Demensfonden; Loo and Hans Osterman Foundation for Medical Research; the Knowledge Foundation; Swedish Research Council.

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睡眠健康状况不佳与大脑衰老有关：全身性炎症的作用。

背景：睡眠质量差与痴呆症风险增加有关。我们研究了健康的睡眠模式和老年脑龄之间的关系，以及这在多大程度上是由全身性炎症介导的。方法：该研究包括27,500名来自英国生物银行的成年人（平均年龄54.7岁，54.0%为女性）。五种自我报告的健康睡眠特征（早时型、每天7-8小时睡眠、无失眠、无打鼾、无白天过度嗜睡）被汇总为健康睡眠评分（0-5分），并用于定义三种睡眠模式：健康（≥4分）、中等（2-3分）和差（≤1分）。使用炎症生物标志物的综合指数infla评分来估计低级别炎症。在平均8.9年的随访后，使用基于1079个脑MRI表型的机器学习模型估计脑年龄，并用于计算脑年龄差距（BAG，即脑年龄减去实足年龄）。数据分析采用线性回归和广义结构方程模型。研究结果：在基线时，898名（3.3%）参与者睡眠不良，15283名（55.6%）参与者睡眠中等，11319名（41.2%）参与者睡眠健康。与健康睡眠相比，中度睡眠（β = 0.25 [0.11, 0.40], P = 0.010）和较差睡眠（β = 0.46 [0.05, 0.87], P < 0.001）与BAG显著升高相关。在中介分析中，中、差睡眠与高BAG之间的关联分别由infla评分介导6.81%和10.42%。解读：睡眠不健康可能会加速大脑衰老。这可能是由更高水平的全身性炎症引起的。资金:Alzheimerfonden;Demensfonden;卢和汉斯·奥斯特曼医学研究基金会；知识基础；瑞典研究委员会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

EBioMedicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology

CiteScore

17.70

自引率

0.90%

发文量

579

审稿时长

5 weeks

期刊介绍： eBioMedicine is a comprehensive biomedical research journal that covers a wide range of studies that are relevant to human health. Our focus is on original research that explores the fundamental factors influencing human health and disease, including the discovery of new therapeutic targets and treatments, the identification of biomarkers and diagnostic tools, and the investigation and modification of disease pathways and mechanisms. We welcome studies from any biomedical discipline that contribute to our understanding of disease and aim to improve human health.