Remote Diazenylation of Fluorinated Alkyl Iodides via 1,5-HAT.

IF 1.3 4区医学 Q4 CHEMISTRY, MEDICINAL

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI:10.1248/cpb.c25-00506

Masahiro Abe, Akiho Mizukami, Aoi Hirata, Nagisa Yano, Airu Kataoka, Kiyofumi Inamoto

引用次数: 0

Abstract

Herein, we demonstrated a site-selective diazenylation of fluorinated alkyl iodides via 1,5-hydrogen atom transfer using diazonium salts, in combination with iron metal and ferrocene as an inexpensive catalytic system. The reactions proceeded under mild conditions with high regioselectivity, thereby enabling the efficient synthesis of a diverse range of azo compounds that have been difficult to access by traditional synthetic methods.

查看原文本刊更多论文

1,5- hat催化的氟化碘化烷基远端二氮化反应。

在这里，我们展示了一个位点选择性的氟化烷基碘化通过1,5-氢原子转移使用重氮盐，结合铁金属和二茂铁作为一个廉价的催化体系。该反应在温和的条件下进行，具有较高的区域选择性，从而能够有效地合成各种传统合成方法难以获得的偶氮化合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Chemical & pharmaceutical bulletin 医学-化学综合

CiteScore

3.20

自引率

5.90%

发文量

132

审稿时长

1.7 months

期刊介绍： The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below. Topics: Organic chemistry In silico science Inorganic chemistry Pharmacognosy Health statistics Forensic science Biochemistry Pharmacology Pharmaceutical care and science Medicinal chemistry Analytical chemistry Physical pharmacy Natural product chemistry Toxicology Environmental science Molecular and cellular biology Biopharmacy and pharmacokinetics Pharmaceutical education Chemical biology Physical chemistry Pharmaceutical engineering Epidemiology Hygiene Regulatory science Immunology and microbiology Clinical pharmacy Miscellaneous.