The Burden of Ischemic Stroke due to Diet Low in Polyunsaturated Fatty Acids in Global, 1990-2021.

IF 1.5 3区医学 Q3 CLINICAL NEUROLOGY

Cerebrovascular Diseases Pub Date : 2025-10-01 DOI:10.1159/000548110

Dongfeng Wang, Lei Ma, Zhenqiang Li, Gengfan Ye, Maosong Chen

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引用次数: 0

Abstract

Introduction: Comprehensive global and regional assessments of polyunsaturated fatty acid (PUFA)-related ischemic stroke (IS) burden, including age-sex stratification and temporal trends, remain limited.

Methods: Utilizing the Global Burden of Disease (GBD) 2021 database, this study analyzed IS burden attributed to low PUFA diets across 204 countries and territories (1990-2021). Estimated annual percentage changes (EAPCs) for disability-adjusted life years (DALYs) were used to evaluate spatiotemporal trends.

Results: Globally, age-standardized DALY rates declined significantly (EAPC: -1.64, 95% CI: -1.75 to -1.54), yet absolute DALY cases rose 1.45-fold. Gender disparities were evident, with steeper declines in females (EAPC: -1.96) than males (EAPC: -1.35). Western sub-Saharan Africa (0.39) and Afghanistan (0.64) had the highest burden, while high-income North America (0.03) and Taiwan, China (0.02) had the lowest. Sub-Saharan Africa (EAPC: -0.21) showed minimal improvement. The significant increase in Lesotho (EAPC: 2.51) contrasting with high-income Asia Pacific (EAPC: -4.35) and South Korea (EAPC: -6.92). The age-specific trend shows that the DALY rate increases with age, reaching its peak in the 75-79 age group. The annual growth rate of DALY for young adults is higher, while the downward trend is more significant for the older person.

Conclusions: Despite global progress in age-standardized rates, rising absolute DALYs highlight persistent challenges from demographic shifts and metabolic risks. Region-specific policies targeting dietary PUFA intake, fortified foods, and gender-sensitive interventions are critical to mitigating IS burden.

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1990-2021年全球饮食中多不饱和脂肪酸含量低导致的缺血性卒中负担

对多不饱和脂肪酸（PUFA）相关的缺血性卒中（IS）负担的全面全球和区域评估，包括年龄-性别分层和时间趋势，仍然有限。方法：利用全球疾病负担（GBD） 2021数据库，本研究分析了204个国家和地区（1990-2021年）低PUFA饮食导致的IS负担。残障调整生命年（DALYs）的估计年百分比变化（EAPCs）用于评估时空趋势。结果：在全球范围内，年龄标准化DALY率显著下降（EAPC: -1.64, 95% CI: -1.75至-1.54），但绝对DALY病例增加了1.45倍。性别差异明显，女性（EAPC: -1.96）比男性（EAPC: -1.35）下降得更快。西撒哈拉以南非洲（0.39）和阿富汗（0.64）的负担最高，而高收入的北美（0.03）和中国台湾（0.02）的负担最低。撒哈拉以南非洲地区（EAPC: -0.21）改善甚微。与高收入的亚太地区（EAPC: -4.35）和韩国（EAPC: -6.92）相比，莱索托（EAPC: 2.51）的增长显著。按年龄划分的趋势显示，DALY率随年龄增长而增加，在75-79岁年龄组达到峰值。年轻人的DALY年增长率较高，而老年人的下降趋势更为明显。结论：尽管全球在年龄标准化率方面取得了进展，但不断上升的绝对DALYs凸显了人口变化和代谢风险带来的持续挑战。针对膳食多氟化脂肪酸摄入、强化食品和性别敏感干预措施的区域特定政策对于减轻IS负担至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebrovascular Diseases 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.