Association of social isolation and loneliness with incident cancer in A Population-based cohort study.

IF 3.6 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

BMC Public Health Pub Date : 2025-10-01 DOI:10.1186/s12889-025-24558-3

Xiaojuan Liu, Ping Chen, Junru Wang, Zhuoyuan Li, Yongbin Zhu, Jiafei Yang, Liqun Wang, Shulan He, Xian Sun, Jiangping Li, Huifang Yang

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引用次数: 0

Abstract

Background: Social isolation and loneliness pose significant public health challenges globally. This study aims to examine the association of social isolation, loneliness and their combined effects with incident cancer.

Methods: This study utilized data from the UK Biobank (UKB), which is a population-based prospective cohort. Social isolation and loneliness were assessed through self-reported questionnaires. Cancer cases were identified by linking to cancer registries.

Results: A total of 430,376 participants were included, during a mean follow-up of 14.32 years, 45,131 participants were diagnosed with cancer. Compared to participants in least isolated group, those in most isolated group had significantly higher risks of cancer of lip, oral cavity and pharynx (HR 1.32, 95% CI 1.11-1.58), cancer of digestive organs (HR 1.10, 95% CI 1.03-1.16), cancer of respiratory and intrathoracic organs (HR 1.17, 95% CI 1.07-1.28), breast cancer (HR 1.11, 95% CI 1.04-1.18), cancer of female genital organs (HR 1.23, 95% CI 1.09-1.38), and cancer of urinary tract (HR 1.31, 95% CI 1.17-1.46). However, the most isolated group had lower risks of cancer of mesothelial and soft tissue (HR 0.80, 95% CI 0.64-0.99), prostate cancer (HR 0.88, 95% CI 0.83-0.94). Individuals with loneliness had a significantly increased risk of cancer of urinary tract (HR 1.19, 95% CI 1.01-1.40), but a reduced risk of cancer of skin (HR 0.76, 95% CI 0.61-0.93).

Conclusions: Social isolation and loneliness were independently associated with incident cancer, with implications for early effective cancer prevention.

查看原文本刊更多论文

一项以人群为基础的队列研究：社会隔离和孤独与癌症发病率的关系

背景：社会隔离和孤独对全球公共卫生构成重大挑战。本研究旨在探讨社会孤立、孤独感及其与癌症发生的综合影响之间的关系。方法：本研究利用了英国生物银行（UKB）的数据，这是一个基于人群的前瞻性队列研究。社会孤立和孤独感通过自我报告的问卷进行评估。通过与癌症登记处的联系来确定癌症病例。结果：共纳入430,376名参与者，在平均14.32年的随访期间，45131名参与者被诊断患有癌症。与最不孤立组的参与者相比，最孤立组的参与者患唇癌、口腔癌和咽癌（HR 1.32, 95% CI 1.11-1.58）、消化器官癌（HR 1.10, 95% CI 1.03-1.16）、呼吸和胸内器官癌（HR 1.17, 95% CI 1.07-1.28）、乳腺癌（HR 1.11, 95% CI 1.04-1.18）、女性生殖器官癌（HR 1.23, 95% CI 1.09-1.38）和尿道癌（HR 1.31, 95% CI 1.17-1.46）的风险明显更高。然而，最孤立的组患间皮癌和软组织癌的风险较低（HR 0.80, 95% CI 0.64-0.99），前列腺癌（HR 0.88, 95% CI 0.83-0.94）。孤独的个体患尿路癌的风险显著增加（HR 1.19, 95% CI 1.01-1.40），但患皮肤癌的风险降低（HR 0.76, 95% CI 0.61-0.93）。结论：社会孤立和孤独感与癌症发病率独立相关，对早期有效预防癌症具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

4.40%

发文量

2108

审稿时长

1 months

期刊介绍： BMC Public Health is an open access, peer-reviewed journal that considers articles on the epidemiology of disease and the understanding of all aspects of public health. The journal has a special focus on the social determinants of health, the environmental, behavioral, and occupational correlates of health and disease, and the impact of health policies, practices and interventions on the community.