Joint transcriptome-wide and proteomic analysis of the mechanisms underlying the regulation of sheep wool fiber diameter.

IF 2.5 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animal Bioscience Pub Date : 2025-09-30 DOI:10.5713/ab.25.0378

Lin Yue, Zengkui Lu, Tingting Guo, Bowen Chen, Jianbin Liu, Chao Yuan

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Abstract

Objective: Wool fiber diameter is a crucial phenotypic trait of wool and a key determinant of its economic value. Deciphering the regulatory mechanisms that influence wool fiber diameter is a fundamental approach to optimizing wool fineness.

Methods: In this study, fine-wool Alpine Merino sheep exhibiting three distinct fiber diameter ranges were selected for comprehensive whole-transcriptome and proteome analyses of skin tissues.

Result: This led to the identification of key microRNAs (oar-miR-23a, oar-miR-23b, oar-miR-150, and oar-miR-218a), critical circular RNAs (circRNA3051, circRNA0315, and circRNA_1477), and multiple pivotal genes (LOC10112037, LOC105614079, IGFBP1, IGFBP4, and MAPK9). Correlation analysis employed to construct an integrative regulatory network suggested a strong association between modulation of wool fiber diameter and metabolism of energy and lipids.

Conclusion: These findings further elucidate the biological mechanisms governing the regulation of wool fiber diameter, providing a theoretical foundation for advancing the wool industry through refinement of wool diameter and enhancements in wool quality.

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绵羊羊毛纤维直径调控机制的联合转录组和蛋白质组学分析。

目的：羊毛纤维直径是羊毛的重要表型性状，是决定羊毛经济价值的关键因素。破译影响羊毛纤维直径的调节机制是优化羊毛细度的基本方法。方法：选择三种不同纤维直径范围的高山美利奴细毛羊，对其皮肤组织进行全转录组和蛋白质组分析。结果：这导致鉴定出关键microrna （mir -23a、mir -23b、mir -150和mir -218a）、关键环状rna （circRNA3051、circRNA0315和circRNA_1477）和多个关键基因（LOC10112037、LOC105614079、IGFBP1、IGFBP4和MAPK9）。通过相关分析构建的综合调控网络表明，羊毛纤维直径的调节与能量和脂质代谢密切相关。结论：这些发现进一步阐明了羊毛纤维直径调控的生物学机制，为进一步推进羊毛工业细化羊毛直径、提高羊毛质量提供了理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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