Aminoquinoline-Directed Electrochemical Cobalt-Catalyzed C(sp²)–H Alkoxylation

Abstract

Electrochemically, earth-abundant cobalt(II)-catalyzed C(sp²)–H alkoxylation of ferrocenyl and arenyl amides with 8-aminoquinoline directing groups was developed under mild, oxidant-free conditions. This protocol afforded a broad range of alkoxylated products in moderate to high yields, employing readily available alcohols as both alkoxy sources and green solvents. Notably, this method enabled efficient C–O bond formation via sustainable electrolysis and offered a practical route to alkylated organic compounds.