Enantioselective palladium-catalyzed carbonylation toward N-N axially chiral amides.

Abstract

N-N axially chiral amides are widely present in various bioactive molecules, yet their catalytic asymmetric synthesis remains a major and persistent challenge. In this work, we report a novel palladium-catalyzed enantioselective carbonylation reaction for the efficient construction of N-N axially chiral amides. This strategy constitutes a significant and innovative advancement in the application of asymmetric carbonylation to access such chiral scaffolds. Notably, by simply modulating the substituent positions, both enantiomers of the product can be obtained, thereby eliminating the need for additional chiral ligands to achieve stereocontrol.